Literature DB >> 9694521

Acute tryptophan depletion attenuates the prolactin response to d-fenfluramine challenge in healthy human subjects.

E F Coccaro1, R J Kavoussi, T B Cooper, R Hauger.   

Abstract

Prolactin responses to d-fenfluramine (d-FEN) Challenge (0.5 mg/kg PO) were examined after pretreatment with and without acute tryptophan depletion (ATD) in six physically healthy male volunteers. Compared to pretreatment with SHAM-ATD, ATD pretreatment attenuated the PRL response to d-FEN Challenge in all subjects. These data suggest that PRL responses to cl-FEN challenge reflect to a substantial degree the activity of newly synthesized 5-HT.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9694521     DOI： 10.1007/s002130050639

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  7 in total

1.  Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice.

Authors:  J P R Jacobsen; W B Siesser; B D Sachs; S Peterson; M J Cools; V Setola; J H A Folgering; G Flik; M G Caron
Journal:  Mol Psychiatry       Date:  2011-05-03       Impact factor: 15.992

2.  Brain serotonin deficiency and fluoxetine lead to sex-specific effects on binge-like food consumption in mice.

Authors:  Melinda D Karth; Brittany J Baugher; Sophia A Pellechia; Shama N Huq; Allison K Warner; Michelle M Karth; Benjamin D Sachs
Journal:  Psychopharmacology (Berl)       Date:  2022-06-24       Impact factor: 4.415

3.  Aggression, suicidality, and intermittent explosive disorder: serotonergic correlates in personality disorder and healthy control subjects.

Authors:  Emil F Coccaro; Royce Lee; Richard J Kavoussi
Journal:  Neuropsychopharmacology       Date:  2010-01       Impact factor: 7.853

Review 4.  Corticosteroid-serotonin interactions in depression: a review of the human evidence.

Authors:  Richard J Porter; Peter Gallagher; Stuart Watson; Allan H Young
Journal:  Psychopharmacology (Berl)       Date:  2004-03-09       Impact factor: 4.530

5.  The Effects of Tryptophan Enhancement and Depletion on Plasma Catecholamine Levels in Healthy Individuals.

Authors:  Stephen H Boyle; Beverly H Brummett; Cynthia M Kuhn; John C Barefoot; Ilene C Siegler; Redford B Williams; Anastasia Georgiades
Journal:  Psychosom Med       Date:  2019-01       Impact factor: 4.312

6.  Impact of acute tryptophan depletion on mood and eating-related urges in bulimic and nonbulimic women.

Authors:  Kenneth R Bruce; Howard Steiger; Simon N Young; N M K Ng Ying Kin; Mimi Israël; Mélissa Lévesque
Journal:  J Psychiatry Neurosci       Date:  2009-09       Impact factor: 6.186

7.  Sleep-wake mechanisms and drug discovery: sleep EEG as a tool for the development of CNS-acting drugs.

Authors:  Luc Staner
Journal:  Dialogues Clin Neurosci       Date:  2002-12       Impact factor: 5.986
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.