Literature DB >> 9694229

GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged parkinsonian mice.

I Date1, M Aoi, S Tomita, F Collins, T Ohmoto.   

Abstract

Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor beta superfamily and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF was injected stereotaxically into the striatum of young (2 months old) and aged (12 months old) C57BL/6 mice that were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 1 week earlier. Immunocytochemical and neurochemical analyses showed significant recovery of the nigrostriatal dopaminergic system both in young and in aged mice. Since Parkinson's disease is a neurodegenerative disorder mainly affecting elderly people, this result demonstrates the potential usefulness of GDNF in treating Parkinson's disease.

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Year:  1998        PMID： 9694229     DOI： 10.1097/00001756-199807130-00039

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  10 in total

1.  Evoked dopamine overflow is augmented in the striatum of calcitriol treated rats.

Authors:  Wayne A Cass; Laura E Peters; Anita M Fletcher; David M Yurek
Journal:  Neurochem Int       Date:  2011-11-22       Impact factor: 3.921

2.  Intravenous treatment of experimental Parkinson's disease in the mouse with an IgG-GDNF fusion protein that penetrates the blood-brain barrier.

Authors:  Ailing Fu; Qing-Hui Zhou; Eric Ka-Wai Hui; Jeff Zhiqiang Lu; Ruben J Boado; William M Pardridge
Journal:  Brain Res       Date:  2010-06-30       Impact factor: 3.252

3.  Availability of Pre- and Pro-regions of Transgenic GDNF Affects the Ability to Induce Axonal Sprout Growth.

Authors:  Nadezda Kust; Dmitri Panteleev; Ilya Mertsalov; Ekaterina Savchenko; Ekaterina Rybalkina; Alexander Revishchin; Galina Pavlova
Journal:  Mol Neurobiol       Date:  2014-07-03       Impact factor: 5.590

Review 4.  Roles for the TGFβ superfamily in the development and survival of midbrain dopaminergic neurons.

Authors:  Shane V Hegarty; Aideen M Sullivan; Gerard W O'Keeffe
Journal:  Mol Neurobiol       Date:  2014-02-07       Impact factor: 5.590

5.  Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

Authors:  O Eberhardt; R V Coelln; S Kugler; J Lindenau; S Rathke-Hartlieb; E Gerhardt; S Haid; S Isenmann; C Gravel; A Srinivasan; M Bahr; M Weller; J Dichgans; J B Schulz
Journal:  J Neurosci       Date:  2000-12-15       Impact factor: 6.167

Review 6.  Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTP-induced Parkinsonism via activation of tyrosine kinase receptor signaling pathway.

Authors:  Silvia A Mandel; Yotam Sagi; Tamar Amit
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7.  The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior.

Authors:  Vandana Zaman; Heather A Boger; Ann-Charlotte Granholm; Baerbel Rohrer; Alfred Moore; Mona Buhusi; Greg A Gerhardt; Barry J Hoffer; Lawrence D Middaugh
Journal:  Eur J Neurosci       Date:  2008-10       Impact factor: 3.386

8.  Geraniol ameliorates the motor behavior and neurotrophic factors inadequacy in MPTP-induced mice model of Parkinson's disease.

Authors:  Karamkolly R Rekha; Govindasamy P Selvakumar; Subramaniam Sethupathy; Karunanidhi Santha; Ramu Inmozhi Sivakamasundari
Journal:  J Mol Neurosci       Date:  2013-08-13       Impact factor: 3.444

Review 9.  Microglia-Mediated Neuroinflammation and Neurotrophic Factor-Induced Protection in the MPTP Mouse Model of Parkinson's Disease-Lessons from Transgenic Mice.

Authors:  Venissa Machado; Tanja Zöller; Abdelraheim Attaai; Björn Spittau
Journal:  Int J Mol Sci       Date:  2016-01-26       Impact factor: 5.923

10.  Repetitive transcranial magnetic stimulation (rTMS) improves behavioral and biochemical deficits in levodopa-induced dyskinetic rats model.

Authors:  Maowen Ba; Min Kong; Lina Guan; Maoli Yi; Hongli Zhang
Journal:  Oncotarget       Date:  2016-09-13
  10 in total

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