Literature DB >> 9691181

Cloning of a human "epidermal-type" 12-lipoxygenase-related gene and chromosomal localization to 17p13.

D Sun1, S H Elsea, P I Patel, C D Funk.   

Abstract

A human "epidermal-type" 12-lipoxygenase (e-12LO) pseudogene was cloned using a murine e-12LO cDNA probe. Similar to other lipoxygenase genes, the genomic sequence revealed 14 exons and 13 introns covering 6.7 kb of DNA. cDNA corresponding to this gene was amplified from RNA of human skin and hair follicles by RACE-PCR and displayed 65-80% identity to the three murine 12-lipoxygenase cDNAs. Based on several criteria, humans appear to lack a functional e-12LO gene but instead have acquired an expressed pseudogene. The pseudogene designated ALOX12P2 was localized to chromosome 17p13 by analysis of somatic hybrid DNA panels.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9691181     DOI： 10.1159/000014993

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  8 in total

Review 1.  Who is the real 12-HETrE?

Authors:  Jennifer Yeung; Michael Holinstat
Journal:  Prostaglandins Other Lipid Mediat       Date:  2017-03-01       Impact factor: 3.072

2.  Diversity of mouse lipoxygenases: identification of a subfamily of epidermal isozymes exhibiting a differentiation-dependent mRNA expression pattern.

Authors:  M Heidt; G Fürstenberger; S Vogel; F Marks; P Krieg
Journal:  Lipids       Date:  2000-07       Impact factor: 1.880

3.  Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia.

Authors:  Ann M Gregus; Darren S Dumlao; Spencer C Wei; Paul C Norris; Laura C Catella; Flore G Meyerstein; Matthew W Buczynski; Joanne J Steinauer; Bethany L Fitzsimmons; Tony L Yaksh; Edward A Dennis
Journal:  FASEB J       Date:  2013-02-04       Impact factor: 5.191

4.  Homology modeling of 5-lipoxygenase and hints for better inhibitor design.

Authors:  P Aparoy; R N Reddy; Lalitha Guruprasad; M R Reddy; P Reddanna
Journal:  J Comput Aided Mol Des       Date:  2008-01-30       Impact factor: 3.686

5.  Oncogenic activation of MAP kinase by BRAF pseudogene in thyroid tumors.

Authors:  Minjing Zou; Essa Y Baitei; Ali S Alzahrani; Futwan Al-Mohanna; Nadir R Farid; Brian Meyer; Yufei Shi
Journal:  Neoplasia       Date:  2009-01       Impact factor: 5.715

Review 6.  Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.

Authors:  Matthew W Buczynski; Darren S Dumlao; Edward A Dennis
Journal:  J Lipid Res       Date:  2009-02-24       Impact factor: 5.922

Review 7.  Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling.

Authors:  Thomas Horn; Susan Adel; Ralf Schumann; Saubashya Sur; Kumar Reddy Kakularam; Aparoy Polamarasetty; Pallu Redanna; Hartmut Kuhn; Dagmar Heydeck
Journal:  Prog Lipid Res       Date:  2014-11-28       Impact factor: 16.195

8.  Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging.

Authors:  Marjann Schäfer; Kumar R Kakularam; Florian Reisch; Michael Rothe; Sabine Stehling; Dagmar Heydeck; Gerhard P Püschel; Hartmut Kuhn
Journal:  Biomedicines       Date:  2022-06-10
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.