Literature DB >> 9691002

Fetal gene reactivation.

R A Swank1, G Stamatoyannopoulos.   

Abstract

Reactivation of silent fetal or embryonic genes could be used for the treatment of genetic diseases caused by mutations of genes normally expressed during the adult stage of development. A paradigm of this approach is the activation of fetal hemoglobin synthesis in adult individuals and its use in the treatment of beta chain hemoglobinopathies. The current understanding of the molecular control of the beta globin locus is reviewed, as are the cellular and molecular basis of induction of fetal hemoglobin in the adult and the approaches used for stimulation of fetal hemoglobin synthesis in patients with beta chain hemoglobinopathies.

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Year:  1998        PMID： 9691002     DOI： 10.1016/s0959-437x(98)80095-6

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  9 in total

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Authors:  Douglas R Higgs; William G Wood
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-11       Impact factor: 11.205

2.  The presence of transcription factors in chicken albumin, yolk and blastoderm.

Authors:  P A Knepper; C S Mayanil; E Hayes; W Goossens; R W Byrne; D G McLone
Journal:  In Vitro Cell Dev Biol Anim       Date:  1999-06       Impact factor: 2.416

3.  Increase in gamma-globin mRNA content in human erythroid cells treated with angelicin analogs.

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Journal:  Int J Hematol       Date:  2009-09-25       Impact factor: 2.490

4.  Triplex-forming peptide nucleic acids induce heritable elevations in gamma-globin expression in hematopoietic progenitor cells.

Authors:  Joanna Y Chin; Faisal Reza; Peter M Glazer
Journal:  Mol Ther       Date:  2013-01-22       Impact factor: 11.454

5.  A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction.

Authors:  Cristina Zuccato; Laura Breda; Francesca Salvatori; Giulia Breveglieri; Sara Gardenghi; Nicoletta Bianchi; Eleonora Brognara; Ilaria Lampronti; Monica Borgatti; Stefano Rivella; Roberto Gambari
Journal:  Ann Hematol       Date:  2012-03-31       Impact factor: 3.673

6.  Genetic variants at HbF-modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania.

Authors:  Siana Nkya Mtatiro; Julie Makani; Bruno Mmbando; Swee Lay Thein; Stephan Menzel; Sharon E Cox
Journal:  Am J Hematol       Date:  2014-10-20       Impact factor: 10.047

7.  Positive selection of DNA-protein interactions in mammalian cells through phenotypic coupling with retrovirus production.

Authors:  Ulrich Tschulena; Kenneth R Peterson; Beatriz Gonzalez; Halyna Fedosyuk; Carlos F Barbas
Journal:  Nat Struct Mol Biol       Date:  2009-10-18       Impact factor: 15.369

8.  Fetal Hemoglobin Inducers from the Natural World: A Novel Approach for Identification of Drugs for the Treatment of {beta}-Thalassemia and Sickle-Cell Anemia.

Authors:  Nicoletta Bianchi; Cristina Zuccato; Ilaria Lampronti; Monica Borgatti; Roberto Gambari
Journal:  Evid Based Complement Alternat Med       Date:  2007-12-11       Impact factor: 2.629

9.  The Hellenic type of nondeletional hereditary persistence of fetal hemoglobin results from a novel mutation (g.-109G>T) in the HBG2 gene promoter.

Authors:  Christos Chassanidis; Angelos Kalamaras; Marios Phylactides; Farzin Pourfarzad; Sophia Likousi; Vassilis Maroulis; Manoussos N Papadakis; Nikolaos K Vamvakopoulos; Vassiliki Aleporou-Marinou; George P Patrinos; Panagoula Kollia
Journal:  Ann Hematol       Date:  2008-12-03       Impact factor: 3.673
  9 in total

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