PROBLEM: Lactating women recover from pregnancy-induced immunosuppression while actively secreting immunologically active agents into milk. Few clinical studies have examined changes in postpartum maternal immune status or explored mechanisms. METHOD OF STUDY: We measured blood B-cell (CD19+) percentages and serum concentrations of immunoglobulin (Ig) G, IgM, and IgA at 1 to 2 weeks, 1 month, and 2 months postpartum in a longitudinal study of seven healthy, lactating women. RESULTS: More frequent or extended breast-feeding sessions were correlated with lower CD19+ percentages, reduced serum IgG, and higher serum IgA and IgM concentrations. CD19+ percentages were correlated negatively with serum prolactin concentrations. Blood samples drawn before and 30 min after breast-feeding did not differ in CD19+ percentages or serum Ig concentrations. CONCLUSIONS: These findings confirm our previous cross-sectional study showing a negative correlation between CD19+ percentages and serum prolactin. Because lactation practices are modifiable, these findings suggest that women can influence the course of lactation-associated immunologic changes.
PROBLEM: Lactating women recover from pregnancy-induced immunosuppression while actively secreting immunologically active agents into milk. Few clinical studies have examined changes in postpartum maternal immune status or explored mechanisms. METHOD OF STUDY: We measured blood B-cell (CD19+) percentages and serum concentrations of immunoglobulin (Ig) G, IgM, and IgA at 1 to 2 weeks, 1 month, and 2 months postpartum in a longitudinal study of seven healthy, lactating women. RESULTS: More frequent or extended breast-feeding sessions were correlated with lower CD19+ percentages, reduced serum IgG, and higher serum IgA and IgM concentrations. CD19+ percentages were correlated negatively with serum prolactin concentrations. Blood samples drawn before and 30 min after breast-feeding did not differ in CD19+ percentages or serum Ig concentrations. CONCLUSIONS: These findings confirm our previous cross-sectional study showing a negative correlation between CD19+ percentages and serum prolactin. Because lactation practices are modifiable, these findings suggest that women can influence the course of lactation-associated immunologic changes.
Authors: Bihui Huang; Azure N Faucette; Michael D Pawlitz; Bo Pei; Joshua W Goyert; Jordan Zheng Zhou; Nadim G El-Hage; Jie Deng; Jason Lin; Fayi Yao; Robert S Dewar; Japnam S Jassal; Maxwell L Sandberg; Jing Dai; Montserrat Cols; Cong Shen; Lisa A Polin; Ronald A Nichols; Theodore B Jones; Martin H Bluth; Karoline S Puder; Bernard Gonik; Nihar R Nayak; Elizabeth Puscheck; Wei-Zen Wei; Andrea Cerutti; Marco Colonna; Kang Chen Journal: Nat Med Date: 2016-12-05 Impact factor: 53.440
Authors: Carmen Clapp; Norma Adán; María G Ledesma-Colunga; Mariana Solís-Gutiérrez; Jakob Triebel; Gonzalo Martínez de la Escalera Journal: Cell Mol Life Sci Date: 2016-03-29 Impact factor: 9.261
Authors: Annika Gunst; My Sundén; Riikka Korja; Amy M Boddy; Jennifer Kotler; E Juulia Paavonen; Henna-Maria Uusitupa; Linnea Karlsson; Hasse Karlsson; Jan Antfolk Journal: Evol Med Public Health Date: 2021-01-02