OBJECTIVE: As part of a study on hormones and bone density in older women, we measured a number of steroid and polypeptide hormones at 4- to 6-month intervals in 32 women over a 10-year period. DESIGN: All women were postmenopausal during this time and all measurements from 12 months after the menopause to the end were used in the analysis. To determine whether there was a significant trend in steroid or polypeptide hormones over the years, the data were analyzed by random coefficient linear regression against number of months since menopause. RESULTS: There was no significant trend in the concentrations of estrone, estrone sulfate, dehydroepiandrosterone, and follicle stimulating hormone. There was a significant decline in the concentrations of estradiol, dihydrotestosterone, dehydroepiandrosterone sulfate, and luteinizing hormone. There was a rise in the levels of androstenedione and testosterone. CONCLUSIONS: The changes in the concentration of sex hormone-binding globulin could be fitted to a quadratic equation with an initial rise in the concentration followed by a decline. Thus, the trend in hormone concentrations shows no set pattern with aging in the postmenopausal years.
OBJECTIVE: As part of a study on hormones and bone density in older women, we measured a number of steroid and polypeptide hormones at 4- to 6-month intervals in 32 women over a 10-year period. DESIGN: All women were postmenopausal during this time and all measurements from 12 months after the menopause to the end were used in the analysis. To determine whether there was a significant trend in steroid or polypeptide hormones over the years, the data were analyzed by random coefficient linear regression against number of months since menopause. RESULTS: There was no significant trend in the concentrations of estrone, estrone sulfate, dehydroepiandrosterone, and follicle stimulating hormone. There was a significant decline in the concentrations of estradiol, dihydrotestosterone, dehydroepiandrosterone sulfate, and luteinizing hormone. There was a rise in the levels of androstenedione and testosterone. CONCLUSIONS: The changes in the concentration of sex hormone-binding globulin could be fitted to a quadratic equation with an initial rise in the concentration followed by a decline. Thus, the trend in hormone concentrations shows no set pattern with aging in the postmenopausal years.
Authors: John Henry Dasinger; Suttira Intapad; Benjamin R Rudsenske; Gwendolyn K Davis; Ashley D Newsome; Barbara T Alexander Journal: Hypertension Date: 2016-04-25 Impact factor: 10.190
Authors: Yasmin A Harrington; Jeanine M Parisi; Daisy Duan; Darlynn M Rojo-Wissar; Calliope Holingue; Adam P Spira Journal: Front Aging Neurosci Date: 2022-07-14 Impact factor: 5.702