Literature DB >> 9688751

Effects of microgravity and bone morphogenetic protein II on GFAP in rat brain.

J R Day1, A T Frank, J P O'Callaghan, B W DeHart.   

Abstract

This study evaluated effects of bone morphogenetic protein II (BMP) on glial fibrillary acidic protein (GFAP) in the brain of female Fischer 344 rats during 14 days of spaceflight. GFAP mRNA decreased in vehicle-implanted rats flown on the space shuttle by 53 and 48% in the stratum moleculare and stratum lacunosum moleculare hippocampal subregions, respectively. GFAP mRNA was not significantly affected by BMP implantation during spaceflight. Rats returning from space exhibited a 56% increase in serum corticosterone. BMP treatment did not additively increase corticosterone elevations in microgravity but appeared to increase serum corticosterone and reduce GFAP mRNA in the stratum moleculare in control rats. These data suggest that exposure to microgravity reduces GFAP expression in hippocampal astrocytes.

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Year:  1998        PMID： 9688751     DOI： 10.1152/jappl.1998.85.2.716

Source DB:  PubMed          Journal:  J Appl Physiol (1985)        ISSN： 0161-7567


  7 in total

1.  Effects of simulated microgravity on the development and maturation of dissociated cortical neurons.

Authors:  Alessio Crestini; Cristina Zona; Pierluigi Sebastiani; Massimo Pieri; Valentina Caracciolo; Lorenzo Malvezzi-Campeggi; Annamaria Confaloni; Silvia Di Loreto
Journal:  In Vitro Cell Dev Biol Anim       Date:  2004 May-Jun       Impact factor: 2.416

2.  Dynamic Foot Stimulations During Short-Term Hindlimb Unloading Prevent Dysregulation of the Neurotransmission in the Hippocampus of Rats.

Authors:  Anna S Berezovskaya; Sergey A Tyganov; Svetlana D Nikolaeva; Alexandra A Naumova; Natalia S Merkulyeva; Boris S Shenkman; Margarita V Glazova
Journal:  Cell Mol Neurobiol       Date:  2020-07-18       Impact factor: 5.046

Review 3.  Brain development, environment and sex: what can we learn from studying graviperception, gravitransduction and the gravireaction of the developing CNS to altered gravity?

Authors:  Elizabeth M Sajdel-Sulkowska
Journal:  Cerebellum       Date:  2008       Impact factor: 3.847

4.  Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation.

Authors:  Linda Rubinstein; Ann-Sofie Schreurs; Samantha M Torres; Sonette Steczina; Moniece G Lowe; Frederico Kiffer; Antiño R Allen; April E Ronca; Marianne B Sowa; Ruth K Globus; Candice G T Tahimic
Journal:  NPJ Microgravity       Date:  2021-07-06       Impact factor: 4.415

5.  Actin microfilament mediates osteoblast Cbfa1 responsiveness to BMP2 under simulated microgravity.

Authors:  Zhongquan Dai; Feng Wu; Jian Chen; Hongjie Xu; Honghui Wang; Feima Guo; Yingjun Tan; Bai Ding; Jinfu Wang; Yumin Wan; Yinghui Li
Journal:  PLoS One       Date:  2013-05-10       Impact factor: 3.240

6.  Cytoskeleton Markers in the Spinal Cord and Mechanoreceptors of Thick-Toed Geckos after Prolonged Space Flights.

Authors:  Alexandra Proshchina; Victoria Gulimova; Anastasia Kharlamova; Yuliya Krivova; Valeriy Barabanov; Sergey Saveliev
Journal:  Life (Basel)       Date:  2022-01-11

7.  Spaceflight induces oxidative damage to blood-brain barrier integrity in a mouse model.

Authors:  Xiao W Mao; Nina C Nishiyama; Stephanie D Byrum; Seta Stanbouly; Tamako Jones; Jacob Holley; Vijayalakshmi Sridharan; Marjan Boerma; Alan J Tackett; Jeffrey S Willey; Michael J Pecaut; Michael D Delp
Journal:  FASEB J       Date:  2020-09-26       Impact factor: 5.834
  7 in total

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