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Literature DB >> 9687485

Fungal biotransformation of 6-nitrochrysene.

J V Pothuluri¹, J B Sutherland, J P Freeman, C E Cerniglia.

Abstract

The fungus Cunninghamella elegans was used to biotransform 6-nitrochrysene, a mutagen that is a widespread environmental contaminant. After 6 days, 74% of the 3H-labeled 6-nitrochrysene added had been metabolized to two isomeric sulfate conjugates. These conjugates were separated by high-performance liquid chromatography and identified by UV-visible, 1H nuclear magnetic resonance, and mass spectral techniques as 6-nitrochrysene 1-sulfate and 6-nitrochrysene 2-sulfate.

Entities: Chemical Species

Mesh：

Substances：
Chrysenes
6-nitrochrysene

Year: 1998 PMID： 9687485 PMCID： PMC106827

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

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References

31 in total

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Fungal biotransformation of 6-nitrochrysene.

1. Aryl hydrocarbon hydroxylase activity in the fungus Cunninghamella bainieri: evidence for the presence of cytochrome P-450.

Review 2. Fungal metabolism of polycyclic aromatic hydrocarbons: past, present and future applications in bioremediation.

3. Identification of trans-1,2-dihydro-1,2-dihydroxy-6-nitrochrysene as a major mutagenic metabolite of 6-nitrochrysene.

4. Microbial transformation of 6-nitrobenzo[a]pyrene.

5. Carcinogen-DNA adduct formation in the lungs and livers of preweanling CD-1 male mice following administration of [3H]-6-nitrochrysene, [3H]-6-aminochrysene, and [3H]-1,6-dinitropyrene.

6. Tumorigenicity of nitrated derivatives of pyrene, benz[a]anthracene, chrysene and benzo[a]pyrene in the newborn mouse assay.

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