Literature DB >> 9687360

Huntingtin: a single bait hooks many species.

J F Gusella1, M E MacDonald.   

Abstract

Cloning of the Huntington's disease gene uncovered huntingtin, which is remarkable for its lack of similarity with known proteins despite its large size, approximately 350 kDa. Subsequent experiments established that huntingtin has an as yet unknown function, crucial for embryonic development and neurogenesis. Recent protein trapping to identify huntingtin interactors now reveals that many different prey fall victim to huntingtin bait.

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Year:  1998        PMID： 9687360     DOI： 10.1016/s0959-4388(98)80071-8

Source DB:  PubMed          Journal:  Curr Opin Neurobiol        ISSN： 0959-4388            Impact factor:   6.627


  18 in total

Review 1.  Are there multiple pathways in the pathogenesis of Huntington's disease?

Authors:  N Aronin; M Kim; G Laforet; M DiFiglia
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-06-29       Impact factor: 6.237

2.  Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions.

Authors:  Scott L Crick; Murali Jayaraman; Carl Frieden; Ronald Wetzel; Rohit V Pappu
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-30       Impact factor: 11.205

3.  Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1.

Authors:  Tie-Shan Tang; Huiping Tu; Edmond Y W Chan; Anton Maximov; Zhengnan Wang; Cheryl L Wellington; Michael R Hayden; Ilya Bezprozvanny
Journal:  Neuron       Date:  2003-07-17       Impact factor: 17.173

Review 4.  Genetic and pharmacological suppression of polyglutamine-dependent neuronal dysfunction in Caenorhabditis elegans.

Authors:  J Alex Parker; Sébastien Holbert; Emmanuel Lambert; Salima Abderrahmane; Christian Néri
Journal:  J Mol Neurosci       Date:  2004       Impact factor: 3.444

5.  A linear lattice model for polyglutamine in CAG-expansion diseases.

Authors:  Melanie J Bennett; Kathryn E Huey-Tubman; Andrew B Herr; Anthony P West; Scott A Ross; Pamela J Bjorkman
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-22       Impact factor: 11.205

6.  Huntington's Disease: From Mutant Huntingtin Protein to Neurotrophic Factor Therapy.

Authors:  Youssef Sari
Journal:  Int J Biomed Sci       Date:  2011-06

7.  Huntington's disease: the case for genetic modifiers.

Authors:  James F Gusella; Marcy E MacDonald
Journal:  Genome Med       Date:  2009-08-21       Impact factor: 11.117

8.  Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo.

Authors:  Juliana M Woda; Teresa Calzonetti; Paige Hilditch-Maguire; Mabel P Duyao; Ronald A Conlon; Marcy E MacDonald
Journal:  BMC Dev Biol       Date:  2005-08-18       Impact factor: 1.978

9.  Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1.

Authors:  Anatoli B Meriin; Xiaoqian Zhang; Xiangwei He; Gary P Newnam; Yury O Chernoff; Michael Y Sherman
Journal:  J Cell Biol       Date:  2002-06-10       Impact factor: 10.539

Review 10.  Huntington's disease: the past, present, and future search for disease modifiers.

Authors:  Erin B D Clabough
Journal:  Yale J Biol Med       Date:  2013-06-13
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