PURPOSE: To determine when patients with a family history of retinoblastoma and previously normal eye exam develop intraocular disease, and where the new retinoblastoma tumors occur. METHODS: A retrospective chart review of retinoblastoma patients. RESULTS: Sixty-two percent of the first eyes (eyes having a previously normal examination) were diagnosed with retinoblastoma by 6 months of age, 90% by 12 months and 100% by 28 months. For the second eye, 27% were identified by 6 months, 64% by 12 months, 91% by 30 months and 100% by 44 months. The younger the age at initial diagnosis of retinoblastoma, the greater the likelihood that tumors will initially be found in the posterior pole. Macular tumors were diagnosed very early (mean 4 months) and once a retinoblastoma focus had appeared in one eye no new tumors developed in the macula of either eye. CONCLUSION: The timing, location, and number of new retinoblastoma tumors follows a predictable pattern.
PURPOSE: To determine when patients with a family history of retinoblastoma and previously normal eye exam develop intraocular disease, and where the new retinoblastoma tumors occur. METHODS: A retrospective chart review of retinoblastomapatients. RESULTS: Sixty-two percent of the first eyes (eyes having a previously normal examination) were diagnosed with retinoblastoma by 6 months of age, 90% by 12 months and 100% by 28 months. For the second eye, 27% were identified by 6 months, 64% by 12 months, 91% by 30 months and 100% by 44 months. The younger the age at initial diagnosis of retinoblastoma, the greater the likelihood that tumors will initially be found in the posterior pole. Macular tumors were diagnosed very early (mean 4 months) and once a retinoblastoma focus had appeared in one eye no new tumors developed in the macula of either eye. CONCLUSION: The timing, location, and number of new retinoblastoma tumors follows a predictable pattern.
Authors: P-R Rothschild; D Lévy; A Savignoni; L Lumbroso-Le Rouic; I Aerts; M Gauthier-Villars; M Esteve; D Bours; L Desjardins; F Doz; C Lévy-Gabriel Journal: Eye (Lond) Date: 2011-09-16 Impact factor: 3.775
Authors: Junne Kamihara; Franck Bourdeaut; William D Foulkes; Jan J Molenaar; Yaël P Mossé; Akira Nakagawara; Andreu Parareda; Sarah R Scollon; Kami Wolfe Schneider; Alison H Skalet; Lisa J States; Michael F Walsh; Lisa R Diller; Garrett M Brodeur Journal: Clin Cancer Res Date: 2017-07-01 Impact factor: 12.531
Authors: Benjamin A King; Carlos Parra; Yimei Li; Kathleen J Helton; Ibrahim Qaddoumi; Matthew W Wilson; Robert J Ogg Journal: PLoS One Date: 2015-07-31 Impact factor: 3.240