| Literature DB >> 9686773 |
O Rascol1, K Sieradzan, H Peyro-Saint-Paul, C Thalamas, C Brefel-Courbon, J M Senard, P Ladure, J L Montastruc, A Lees.
Abstract
We have tested, in a prospective randomized, double-blind, placebo-controlled, crossover, 12-week study, the effects of 2 mg efaroxan, a potent alpha-2 antagonist, given three times per day to 14 patients with progressive supranuclear palsy. Efaroxan did not induce any significant change on any motor assessment criteria. The present data do not confirm the assumption that the blockade of alpha-2 receptors might be a useful pharmacologic strategy to improve patients with progressive supranuclear palsy.Entities:
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Year: 1998 PMID： 9686773 DOI： 10.1002/mds.870130411
Source DB: PubMed Journal: Mov Disord ISSN： 0885-3185 Impact factor: 10.338