Literature DB >> 9686394

Bacterial cytotoxins target Rho GTPases.

G Schmidt1, K Aktories.   

Abstract

Low molecular mass GTPases of the Rho family, which are involved in the regulation of the actin cytoskeleton and in various signal transduction processes, are the eukaryotic targets of bacterial protein toxins. The toxins covalently modify Rho proteins by ADP ribosylation, glucosylation, and deamidation, thereby inactivating and activating the GTPases.

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Year:  1998        PMID: 9686394     DOI: 10.1007/s001140050495

Source DB:  PubMed          Journal:  Naturwissenschaften        ISSN: 0028-1042


  2 in total

1.  Lysine and polyamines are substrates for transglutamination of Rho by the Bordetella dermonecrotic toxin.

Authors:  G Schmidt; U M Goehring; J Schirmer; S Uttenweiler-Joseph; M Wilm; M Lohmann; A Giese; G Schmalzing; K Aktories
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

2.  Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase.

Authors:  S Wahl; H Barth; T Ciossek; K Aktories; B K Mueller
Journal:  J Cell Biol       Date:  2000-04-17       Impact factor: 10.539

  2 in total

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