Literature DB >> 9685920

An AB block copolymer of oligo(methyl methacrylate) and poly(acrylic acid) for micellar delivery of hydrophobic drugs.

T Inoue1, G Chen, K Nakamae, A S Hoffman.   

Abstract

An AB block copolymer of oligo(methyl methacrylate) (oMMA) and poly(acrylic acid) (PAAc) has been synthesized. The block copolymer forms micelles in an aqueous medium, as confirmed by a fluorescence probe technique using pyrene. Doxorubicin hydrochloride was incorporated into the micelle and the release profile of doxorubicin hydrochloride was investigated. Slow and prolonged release of doxorubicin hydrochloride from the micelle was observed. The AB block copolymer micelle can be useful for prolonged mucosal drug delivery of hydrophobic drugs.

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Year:  1998        PMID： 9685920     DOI： 10.1016/s0168-3659(97)00172-7

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  15 in total

1.  Dendrimeric micelles for controlled drug release and targeted delivery.

Authors:  Ashootosh V Ambade; Elamprakash N Savariar; S Thayumanavan
Journal:  Mol Pharm       Date:  2005 Jul-Aug       Impact factor: 4.939

Review 2.  Oral bioavailability: issues and solutions via nanoformulations.

Authors:  Kamla Pathak; Smita Raghuvanshi
Journal:  Clin Pharmacokinet       Date:  2015-04       Impact factor: 6.447

3.  Utilization of micelles formed from poly(ethylene glycol)-block-poly(epsilon-caprolactone) block copolymers as nanocarriers to enable hydrophobic red two-photon absorbing emitters for cells imaging.

Authors:  Yanqing Tian; Wen-Chung Wu; Ching-Yi Chen; Sei-Hum Jang; Meng Zhang; Tim Strovas; Judy Anderson; Brad Cookson; Yongzhong Li; Deirdre Meldrum; Wen-Chang Chen; Alex K-Y Jen
Journal:  J Biomed Mater Res A       Date:  2010-06-01       Impact factor: 4.396

4.  High-Capacity Drug Carriers from Common Polymer Amphiphiles.

Authors:  Zhun Zhou; Oliver Munyaradzi; Xin Xia; Da'Sean Green; Dennis Bong
Journal:  Biomacromolecules       Date:  2016-08-23       Impact factor: 6.988

Review 5.  Micellar nanocarriers: pharmaceutical perspectives.

Authors:  V P Torchilin
Journal:  Pharm Res       Date:  2006-11-16       Impact factor: 4.200

6.  pH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors.

Authors:  Ching-Yi Chen; Tae Hee Kim; Wen-Chung Wu; Chi-Ming Huang; Hua Wei; Christopher W Mount; Yanqing Tian; Sei-Hum Jang; Suzie H Pun; Alex K-Y Jen
Journal:  Biomaterials       Date:  2013-03-15       Impact factor: 12.479

7.  Porphyrin and galactosyl conjugated micelles for targeting photodynamic therapy.

Authors:  De-Qun Wu; Ze-Yong Li; Cao Li; Jian-Jun Fan; Bo Lu; Cong Chang; Si-Xue Cheng; Xian-Zheng Zhang; Ren-Xi Zhuo
Journal:  Pharm Res       Date:  2009-11-04       Impact factor: 4.200

8.  The effect of polymerization method in stereo-active block copolymers on the stability of polymeric micelles and their drug release profile.

Authors:  Hoda Soleymani Abyaneh; Mohammad Reza Vakili; Afsaneh Lavasanifar
Journal:  Pharm Res       Date:  2014-02-04       Impact factor: 4.200

9.  Role of Branching of Hydrophilic Domain on Physicochemical Properties of Amphiphilic Macromolecules.

Authors:  Dalia Abdelhamid; Hulya Arslan; Yingyue Zhang; Kathryn E Uhrich
Journal:  Polym Chem       Date:  2014-02-21       Impact factor: 5.582

10.  Preparation of poly(NIPAAm)-Pluronic F68 as a thermosensitive surfactant for a controlled drug release.

Authors:  Sung-Wook Choi; Hye Min Lee; Tae-Joon Park; Jung-Hyun Kim
Journal:  Int J Pharm Investig       Date:  2011-04
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