| Literature DB >> 9685690 |
M Ino-ue1, N Ohgiya, M Yamamoto.
Abstract
The effect of aminoguanidine (AG) on structural abnormalities in optic nerve fibers was evaluated in streptozotocin-induced diabetic rats. Morphometry of myelinated optic nerve fibers showed a partial amelioration on the reduction of the axon size but complete preservation of myelin size with low dose (25 mg kg-1 body weight) AG treatment. High dose (100 mg kg-1 body weight) AG completely prevented myelinated nerve fiber atrophy. These findings indicated that nonenzymatic glycation contributes to the development of optic nerve changes in diabetic rats. Copyright 1998 Elsevier Science B.V. All rights reserved.Entities:
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Year: 1998 PMID： 9685690 DOI： 10.1016/s0006-8993(98)00512-5
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252