Literature DB >> 9685662

Cannabinoid receptor CB1 mRNA is highly expressed in the rat ciliary body: implications for the antiglaucoma properties of marihuana.

A Porcella1, P Casellas, G L Gessa, L Pani.   

Abstract

We used RT-PCR to measure relative differences in cannabinoid receptor (CB) mRNAs in the rat eye, comparing CB1 or CB2 transcripts to that of the normalizing reference gene beta2 microglobulin (beta2m). Significantly higher levels of CB1 mRNA levels were found in the ciliary body (0.84+/-0.05% of beta2m) than in the iris, (0.34+/-0.04% of beta2m), retina (0.07+/-0.005% of beta2m) and choroid (0.06+/-0.005% of beta2m). CB2 mRNA was undetectable. This expression pattern supports a specific role for the CB1 receptor in controlling intraocular pressure, helping to explain the antiglaucoma property of cannabinoids. Copyright 1998 Elsevier Science B.V. All rights reserved.

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Year:  1998        PMID： 9685662     DOI： 10.1016/s0169-328x(98)00105-3

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  27 in total

1.  Cannabinoid CB1 receptors and ligands in vertebrate retina: localization and function of an endogenous signaling system.

Authors:  A Straiker; N Stella; D Piomelli; K Mackie; H J Karten; G Maguire
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

2.  Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment.

Authors:  Shakiru O Alapafuja; Michael S Malamas; Vidyanand Shukla; Alexander Zvonok; Sally Miller; Laura Daily; Girija Rajarshi; Christina Yume Miyabe; Honrao Chandrashekhar; JodiAnne Wood; Sergiy Tyukhtenko; Alex Straiker; Alexandros Makriyannis
Journal:  Bioorg Med Chem       Date:  2018-11-03       Impact factor: 3.641

Review 3.  The endocannabinoid system as an emerging target of pharmacotherapy.

Authors:  Pál Pacher; Sándor Bátkai; George Kunos
Journal:  Pharmacol Rev       Date:  2006-09       Impact factor: 25.468

4.  Architecture of cannabinoid signaling in mouse retina.

Authors:  Sherry Shu-Jung Hu; Andy Arnold; Jacqueline M Hutchens; Josh Radicke; Benjamin F Cravatt; Jim Wager-Miller; Ken Mackie; Alex Straiker
Journal:  J Comp Neurol       Date:  2010-09-15       Impact factor: 3.215

5.  Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits.

Authors:  K Laine; T Järvinen; J Savinainen; J T Laitinen; D W Pate; K Järvinen
Journal:  Pharm Res       Date:  2001-04       Impact factor: 4.200

6.  Topical WIN55212-2 alleviates intraocular hypertension in rats through a CB1 receptor mediated mechanism of action.

Authors:  Matt H Oltmanns; Sandeep S Samudre; Ivan G Castillo; Alireza Hosseini; Aron H Lichtman; Robert C Allen; Frank A Lattanzio; Patricia B Williams
Journal:  J Ocul Pharmacol Ther       Date:  2008-02       Impact factor: 2.671

7.  A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway.

Authors:  Chanjuan Shi; Anna Szczesniak; Lucy Mao; Christine Jollimore; Miguel Coca-Prados; Orlando Hung; Melanie E M Kelly
Journal:  Br J Pharmacol       Date:  2003-06       Impact factor: 8.739

Review 8.  Cannabinoids and glaucoma.

Authors:  I Tomida; R G Pertwee; A Azuara-Blanco
Journal:  Br J Ophthalmol       Date:  2004-05       Impact factor: 4.638

9.  Ocular disposition of the hemiglutarate ester prodrug of ∆⁹-Tetrahydrocannabinol from various ophthalmic formulations.

Authors:  Tushar Hingorani; Goutham R Adelli; Nagendra Punyamurthula; Waseem Gul; Mahmoud A Elsohly; Michael A Repka; Soumyajit Majumdar
Journal:  Pharm Res       Date:  2013-06-05       Impact factor: 4.200

10.  Cannabinoid agonists induce relaxation in the bovine ophthalmic artery: evidences for CB1 receptors, nitric oxide and potassium channels.

Authors:  Maria Rosaria Romano; Marcello D Lograno
Journal:  Br J Pharmacol       Date:  2006-04       Impact factor: 8.739
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