Literature DB >> 9685266

Pioneer axon guidance by UNC-129, a C. elegans TGF-beta.

A Colavita1, S Krishna, H Zheng, R W Padgett, J G Culotti.   

Abstract

The unc-129 gene, like the unc-6 netrin gene, is required to guide pioneer motoraxons along the dorsoventral axis of Caenorhabditis elegans. unc-129 encodes a member of the transforming growth factor-beta (TGF-beta) superfamily of secreted signaling molecules and is expressed in dorsal, but not ventral, rows of body wall muscles. Ectopic expression of UNC-129 from ventral body wall muscle disrupts growth cone and cell migrations that normally occur along the dorsoventral axis. Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9685266     DOI： 10.1126/science.281.5377.706

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  76 in total

1.  The NTR module: domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases.

Authors:  L Bányai; L Patthy
Journal:  Protein Sci       Date:  1999-08       Impact factor: 6.725

2.  The DAF-7 TGF-beta signaling pathway regulates chemosensory receptor gene expression in C. elegans.

Authors:  Katherine M Nolan; Trina R Sarafi-Reinach; Jennifer G Horne; Adam M Saffer; Piali Sengupta
Journal:  Genes Dev       Date:  2002-12-01       Impact factor: 11.361

Review 3.  Guidance molecules in synapse formation and plasticity.

Authors:  Kang Shen; Christopher W Cowan
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-03-10       Impact factor: 10.005

4.  The FoxF/FoxC factor LET-381 directly regulates both cell fate specification and cell differentiation in C. elegans mesoderm development.

Authors:  Nirav M Amin; Herong Shi; Jun Liu
Journal:  Development       Date:  2010-03-24       Impact factor: 6.868

Review 5.  Mechanisms and molecules of neuronal wiring: a primer.

Authors:  Alex L Kolodkin; Marc Tessier-Lavigne
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-06-01       Impact factor: 10.005

6.  Caenorhabditis elegans wsp-1 regulation of synaptic function at the neuromuscular junction.

Authors:  Yuqian Zhang; Terrance J Kubiseski
Journal:  J Biol Chem       Date:  2010-05-25       Impact factor: 5.157

7.  CCDC-55 is required for larval development and distal tip cell migration in Caenorhabditis elegans.

Authors:  Ismar Kovacevic; Richard Ho; Erin J Cram
Journal:  Mech Dev       Date:  2012-01-20       Impact factor: 1.882

8.  Caenorhabditis elegans VEM-1, a novel membrane protein, regulates the guidance of ventral nerve cord-associated axons.

Authors:  Erik Runko; Zaven Kaprielian
Journal:  J Neurosci       Date:  2004-10-13       Impact factor: 6.167

9.  Functional analysis of the Caenorhabditis elegans UNC-73B PH domain demonstrates a role in activation of the Rac GTPase in vitro and axon guidance in vivo.

Authors:  Terrance J Kubiseski; Joe Culotti; Tony Pawson
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272

10.  Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis.

Authors:  A Rebbapragada; H Benchabane; J L Wrana; A J Celeste; L Attisano
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.