PURPOSE: The present study compares morphological changes associated with optical defocus-induced myopia (ODM) with those from form deprivation myopia (FDM), as it is yet to be determined whether the latter is a consequence of visual deprivation or active myopic eye growth. METHODS: Hatchling chicks were reared for 2 weeks wearing a monocular translucent occluder or -10.00 D lens, with the other eye used as a control. After enucleation, eyes were processed for scanning electron microscopy. RESULTS: Anatomical profiles of control eyes revealed significant variations in tissue thickness as a function of nasotemporal location. Both FDM and ODM eyes demonstrated similar morphological profiles of retinal thinning, cartilaginous scleral thickening, enlarged photoreceptor inner segments and decreased photoreceptor cell density towards the ora serrata. A graded differential orientation of photoreceptors existed in all eyes. CONCLUSION: The comparable morphological changes in FDM and ODM suggest that the response to altered visual experience is similar in both paradigms.
PURPOSE: The present study compares morphological changes associated with optical defocus-induced myopia (ODM) with those from form deprivation myopia (FDM), as it is yet to be determined whether the latter is a consequence of visual deprivation or active myopic eye growth. METHODS: Hatchling chicks were reared for 2 weeks wearing a monocular translucent occluder or -10.00 D lens, with the other eye used as a control. After enucleation, eyes were processed for scanning electron microscopy. RESULTS: Anatomical profiles of control eyes revealed significant variations in tissue thickness as a function of nasotemporal location. Both FDM and ODM eyes demonstrated similar morphological profiles of retinal thinning, cartilaginous scleral thickening, enlarged photoreceptor inner segments and decreased photoreceptor cell density towards the ora serrata. A graded differential orientation of photoreceptors existed in all eyes. CONCLUSION: The comparable morphological changes in FDM and ODM suggest that the response to altered visual experience is similar in both paradigms.
Authors: Marie-Hélène Errera; Michel Michaelides; Pearse A Keane; Marie Restori; Michel Paques; Anthony T Moore; Jonathan Yeoh; Derek Chan; Catherine A Egan; Praveen J Patel; Adnan Tufail Journal: Graefes Arch Clin Exp Ophthalmol Date: 2014-01-25 Impact factor: 3.117
Authors: Ranjay Chakraborty; Victoria Yang; Han Na Park; Erica G Landis; Susov Dhakal; Cara T Motz; Michael A Bergen; P Michael Iuvone; Machelle T Pardue Journal: Exp Eye Res Date: 2018-12-31 Impact factor: 3.467
Authors: Philipp L Müller; Yuka Kihara; Abraham Olvera-Barrios; Alasdair N Warwick; Catherine Egan; Katie M Williams; Aaron Y Lee; Adnan Tufail Journal: Invest Ophthalmol Vis Sci Date: 2022-08-02 Impact factor: 4.925