BACKGROUNDS/AIMS: The aim of the study was to evaluate the influence of regional versus extended lymphadenectomy on survival in patients with ductal adenocarcinoma of the head of the pancreas. From 1988 to 1996 we performed partial duodeno-pancreatectomies (Whipple procedure) combined with either regional (n = 20, group A) or extended retroperitoneal (n = 33, group B) lymphadenectomy in 53 patients with ductal adenocarcinoma of the pancreas head. METHODOLOGY: The outcome of the two groups was compared by constructing survival curves and evaluating demographic, intraoperative and histopathologic data from all patients (n = 44) with curative (R0) resections. RESULTS: For patients after R0 resection there was no significant difference in terms of survival between group A and B. Only tumor stage (p = 0.0258), portal vein invasion (p = 0.0190) and tumor grade (p = 0.0021) had a significant influence on survival, regardless of the type of operation. CONCLUSION: Our data suggest that no further improvement of the survival rate can be achieved by extended retroperitoneal lymphadenectomy, compared to regional lymphadenectomy.
BACKGROUNDS/AIMS: The aim of the study was to evaluate the influence of regional versus extended lymphadenectomy on survival in patients with ductal adenocarcinoma of the head of the pancreas. From 1988 to 1996 we performed partial duodeno-pancreatectomies (Whipple procedure) combined with either regional (n = 20, group A) or extended retroperitoneal (n = 33, group B) lymphadenectomy in 53 patients with ductal adenocarcinoma of the pancreas head. METHODOLOGY: The outcome of the two groups was compared by constructing survival curves and evaluating demographic, intraoperative and histopathologic data from all patients (n = 44) with curative (R0) resections. RESULTS: For patients after R0 resection there was no significant difference in terms of survival between group A and B. Only tumor stage (p = 0.0258), portal vein invasion (p = 0.0190) and tumor grade (p = 0.0021) had a significant influence on survival, regardless of the type of operation. CONCLUSION: Our data suggest that no further improvement of the survival rate can be achieved by extended retroperitoneal lymphadenectomy, compared to regional lymphadenectomy.
Authors: Jeannine Bachmann; Christoph W Michalski; Marc E Martignoni; Markus W Büchler; Helmut Friess Journal: HPB (Oxford) Date: 2006 Impact factor: 3.647
Authors: Kimberly Moore Dalal; Yanghee Woo; Charles Galanis; Mithat Gonen; Laura Tang; Peter Allen; Ronald DeMatteo; Yuman Fong; Daniel G Coit Journal: J Gastrointest Surg Date: 2007-09-19 Impact factor: 3.452
Authors: Tom C Nguyen; Taylor A Sohn; John L Cameron; Keith D Lillemoe; Kurtis A Campbell; JoAnn Coleman; Patricia K Sauter; Ross A Abrams; Ralph H Hruban; Charles J Yeo Journal: J Gastrointest Surg Date: 2003-01 Impact factor: 3.452