BACKGROUND/AIMS: This study was designed to assess the correlation of interleukin 6 (IL-6) with jaundice reduction by percutaneous transhepatic cholangio-drainage (PTCD) for obstructive jaundice. METHODOLOGY: We measured serum and bile IL-6 concentrations by enzyme linked immuno-sorbent assay before and after PTCD in 26 patients with obstructive jaundice. The patients were divided into two groups according to their bilirubin decrease rate. RESULTS: Serum IL-6 levels measured before and after PTCD in the slowly decreasing bilirubin group ("poor" group) were significantly higher than those of the rapidly decreasing bilirubin group ("good" group). Measures of bile IL-6 in the "poor" group remained high from 3 to 14 days after PTCD in comparison with the "good" group. CONCLUSIONS: These results suggest that circulating IL-6, as well as IL-6 in the bile, may be involved in the pathogenesis of obstructive jaundice, and play an important role in preventing the resolution of obstructive jaundice after PTCD.
BACKGROUND/AIMS: This study was designed to assess the correlation of interleukin 6 (IL-6) with jaundice reduction by percutaneous transhepatic cholangio-drainage (PTCD) for obstructive jaundice. METHODOLOGY: We measured serum and bile IL-6 concentrations by enzyme linked immuno-sorbent assay before and after PTCD in 26 patients with obstructive jaundice. The patients were divided into two groups according to their bilirubin decrease rate. RESULTS: Serum IL-6 levels measured before and after PTCD in the slowly decreasing bilirubin group ("poor" group) were significantly higher than those of the rapidly decreasing bilirubin group ("good" group). Measures of bile IL-6 in the "poor" group remained high from 3 to 14 days after PTCD in comparison with the "good" group. CONCLUSIONS: These results suggest that circulating IL-6, as well as IL-6 in the bile, may be involved in the pathogenesis of obstructive jaundice, and play an important role in preventing the resolution of obstructive jaundice after PTCD.
Authors: Isao Nozaki; John G Lunz; Susan Specht; Jong-In Park; Andrew S Giraud; Noriko Murase; Anthony J Demetris Journal: Am J Pathol Date: 2004-12 Impact factor: 4.307
Authors: Ban Seok Lee; Jin-Hyeok Hwang; Sang Hyub Lee; Sang Eon Jang; Eun Sun Jang; Hyun Jin Jo; Cheol Min Shin; Young Soo Park; Jin-Wook Kim; Sook-Hyang Jung; Nayoung Kim; Dong Ho Lee; Jun Kyu Lee; Soyeon Ahn Journal: Dig Dis Sci Date: 2012-11-22 Impact factor: 3.199