| Literature DB >> 9683888 |
A C Karaplis1, R A Deckelbaum.
Abstract
Parathyroid hormone-related peptide (PTHrP) has important functions in the control of cellular growth and differentiation. Acting, at least in part, through the PTH-1 receptor, PTHrP profoundly influences chondrocytic and osteogenic cell biology. Studies using knockout and transgenic mouse technology have played a pivotal role in unraveling the physiological role of PTHrP and its receptor in endochondral bone development and adult skeletal homeostasis. Further clarification of these functions will have far-reaching implications in our general understanding of skeletogenesis and the pathophysiology of human skeletal disorders.Entities:
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Year: 1998 PMID： 9683888 DOI： 10.2741/a322
Source DB: PubMed Journal: Front Biosci ISSN： 1093-4715