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Literature DB >> 9683609

Commitment to X inactivation precedes the twinning event in monochorionic MZ twins.

J Monteiro¹, C Derom, R Vlietinck, N Kohn, M Lesser, P K Gregersen.

Abstract

To gain insight into the timing of twinning, we have examined a closely related event, X-chromosome inactivation, in female MZ twin pairs. X-inactivation patterns in peripheral blood and buccal mucosa were compared between monochorionic MZ (MC-MZ) and dichorionic MZ (DC-MZ) twins. Overall, the MC-MZ twins displayed highly similar X-inactivation patterns, whereas DC-MZ twins frequently differed in their X-inactivation patterns, when both tissues were tested. Previous experimental data suggest that commitment to X inactivation occurs when there are 10-20 cells in the embryo. Simulation of embryo splitting after commitment to X inactivation suggests that MC-MZ twinning occurs three or four rounds of replication after X inactivation, whereas a DC-MZ twinning event occurs earlier, before or around the time of X inactivation. Finally, the overall degree of skewing in the MZ twins was not significantly different from that observed in singletons. This indicates that X inactivation does not play a direct role in the twinning process, and it further suggests that extreme unequal splitting is not a common mechanism of twin formation.

Entities: Chemical

Mesh：

Substances：
DNA

Year: 1998 PMID： 9683609 PMCID： PMC1377319 DOI： 10.1086/301978

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

17 in total

Review 1. RNA and the epigenetic regulation of X chromosome inactivation.

Authors: B Panning; R Jaenisch
Journal: Cell Date: 1998-05-01 Impact factor: 41.582

2. Do twin Lyons have larger spots?

Authors: W E Nance
Journal: Am J Hum Genet Date: 1990-04 Impact factor: 11.025

3. Prenatal test for X-linked severe combined immunodeficiency by analysis of maternal X-chromosome inactivation and linkage analysis.

Authors: J M Puck; C M Krauss; S M Puck; R H Buckley; M E Conley
Journal: N Engl J Med Date: 1990-04-12 Impact factor: 91.245

4. Discordance of muscular dystrophy in monozygotic female twins: evidence supporting asymmetric splitting of the inner cell mass in a manifesting carrier of Duchenne dystrophy.

Authors: J R Lupski; C A Garcia; H Y Zoghbi; E P Hoffman; R G Fenwick
Journal: Am J Med Genet Date: 1991-09-01

5. X inactivation patterns in female monozygotic twins and their families.

Authors: E Watkiss; T Webb; G Rysiecki; N Girdler; E Hewett; S Bundey
Journal: J Med Genet Date: 1994-10 Impact factor: 6.318

6. Primary non-random X-inactivation caused by controlling elements in the mouse demonstrated at the cellular level.

Authors: S Rastan
Journal: Genet Res Date: 1982-10 Impact factor: 1.588

7. Maximum-likelihood analysis of human T-cell X chromosome inactivation patterns: normal women versus carriers of X-linked severe combined immunodeficiency.

Authors: J M Puck; C C Stewart; R L Nussbaum
Journal: Am J Hum Genet Date: 1992-04 Impact factor: 11.025

8. Skewed X inactivation in a female MZ twin results in Duchenne muscular dystrophy.

Authors: C S Richards; S C Watkins; E P Hoffman; N R Schneider; I W Milsark; K S Katz; J D Cook; L M Kunkel; J M Cortada
Journal: Am J Hum Genet Date: 1990-04 Impact factor: 11.025

9. Oligoclonality in the human CD8+ T cell repertoire in normal subjects and monozygotic twins: implications for studies of infectious and autoimmune diseases.

Authors: J Monteiro; R Hingorani; I H Choi; J Silver; R Pergolizzi; P K Gregersen
Journal: Mol Med Date: 1995-09 Impact factor: 6.354

10. Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation.

Authors: R C Allen; H Y Zoghbi; A B Moseley; H M Rosenblatt; J W Belmont
Journal: Am J Hum Genet Date: 1992-12 Impact factor: 11.025

14 in total

1. A longitudinal study of X-inactivation ratio in human females.

Authors: Ionel Sandovici; Anna K Naumova; Mark Leppert; Yendi Linares; Carmen Sapienza
Journal: Hum Genet Date: 2004-08-28 Impact factor: 4.132

2. Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly.

Authors: N A Oates; J van Vliet; D L Duffy; H Y Kroes; N G Martin; D I Boomsma; M Campbell; M G Coulthard; E Whitelaw; S Chong
Journal: Am J Hum Genet Date: 2006-05-22 Impact factor: 11.025

Review 3. X chromosome inactivation in clinical practice.

Authors: Karen Helene Orstavik
Journal: Hum Genet Date: 2009-04-25 Impact factor: 4.132

Review 4. Expression of the disease on female carriers of X-linked lysosomal disorders: a brief review.

Authors: Louise L C Pinto; Taiane A Vieira; Roberto Giugliani; Ida V D Schwartz
Journal: Orphanet J Rare Dis Date: 2010-05-28 Impact factor: 4.123

5. X-chromosome inactivation patterns in monozygotic twins and sib pairs discordant for nonsyndromic cleft lip and/or palate.

Authors: Jane W Kimani; Min Shi; Sandra Daack-Hirsch; Kaare Christensen; Danilo Moretti-Ferreira; Mary L Marazita; L Leigh Field; John W Canady; Jeffrey C Murray
Journal: Am J Med Genet A Date: 2007-12-15 Impact factor: 2.802

6. New insights into genotype-phenotype correlations for the doublecortin-related lissencephaly spectrum.

Authors: Nadia Bahi-Buisson; Isabelle Souville; Franck J Fourniol; Aurelie Toussaint; Carolyn A Moores; Anne Houdusse; Jean Yves Lemaitre; Karine Poirier; Reham Khalaf-Nazzal; Marie Hully; Pierre Louis Leger; Caroline Elie; Nathalie Boddaert; Cherif Beldjord; Jamel Chelly; Fiona Francis
Journal: Brain Date: 2013-01 Impact factor: 13.501

10. Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins.

Authors: I Ouellet-Morin; C C Y Wong; A Danese; C M Pariante; A S Papadopoulos; J Mill; L Arseneault
Journal: Psychol Med Date: 2012-12-10 Impact factor: 7.723

Commitment to X inactivation precedes the twinning event in monochorionic MZ twins.

Review 1. RNA and the epigenetic regulation of X chromosome inactivation.

2. Do twin Lyons have larger spots?

3. Prenatal test for X-linked severe combined immunodeficiency by analysis of maternal X-chromosome inactivation and linkage analysis.

4. Discordance of muscular dystrophy in monozygotic female twins: evidence supporting asymmetric splitting of the inner cell mass in a manifesting carrier of Duchenne dystrophy.

5. X inactivation patterns in female monozygotic twins and their families.

6. Primary non-random X-inactivation caused by controlling elements in the mouse demonstrated at the cellular level.

7. Maximum-likelihood analysis of human T-cell X chromosome inactivation patterns: normal women versus carriers of X-linked severe combined immunodeficiency.

8. Skewed X inactivation in a female MZ twin results in Duchenne muscular dystrophy.

9. Oligoclonality in the human CD8+ T cell repertoire in normal subjects and monozygotic twins: implications for studies of infectious and autoimmune diseases.

10. Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation.

1. A longitudinal study of X-inactivation ratio in human females.

2. Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly.

Review 3. X chromosome inactivation in clinical practice.

Review 4. Expression of the disease on female carriers of X-linked lysosomal disorders: a brief review.

5. X-chromosome inactivation patterns in monozygotic twins and sib pairs discordant for nonsyndromic cleft lip and/or palate.

6. New insights into genotype-phenotype correlations for the doublecortin-related lissencephaly spectrum.

7. Female monozygotic twins discordant for hemophilia A due to nonrandom X-chromosome inactivation.

Review 8. Autoimmunity in women: an eX_amination of eX_isting models.

9. A longitudinal twin study of skewed X chromosome-inactivation.

10. Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins.

Review 1. RNA and the epigenetic regulation of X chromosome inactivation.

Review 3. X chromosome inactivation in clinical practice.

Review 4. Expression of the disease on female carriers of X-linked lysosomal disorders: a brief review.

Review 8. Autoimmunity in women: an eXamination of eXisting models.

Review 8. Autoimmunity in women: an eX_amination of eX_isting models.