J Ramsay1, G Birrell, M Lavin. 1. Queensland Radium Institute Laboratory and Queensland Institute of Medical Research, Herston, Brisbane, Australia.
Abstract
BACKGROUND AND PURPOSE: To determine if clinical radiosensitivity in breast cancer patients is related to mutations of the ataxia telangiectasia gene (ATM). MATERIALS AND METHODS: Fifteen patients who had developed a severe late reaction to a standard radiotherapy schedule were examined for evidence of increased in vitro radiosensitivity using the MTT assay. Mutation analysis was performed using a protein truncation assay. RESULTS: No mutations were detected in the 15 patients despite evidence of increased in vitro radiosensitivity. CONCLUSIONS: Testing for the ATM gene is unlikely to be useful for predicting clinical response to radiotherapy in breast cancer patients.
BACKGROUND AND PURPOSE: To determine if clinical radiosensitivity in breast cancerpatients is related to mutations of the ataxia telangiectasia gene (ATM). MATERIALS AND METHODS: Fifteen patients who had developed a severe late reaction to a standard radiotherapy schedule were examined for evidence of increased in vitro radiosensitivity using the MTT assay. Mutation analysis was performed using a protein truncation assay. RESULTS: No mutations were detected in the 15 patients despite evidence of increased in vitro radiosensitivity. CONCLUSIONS: Testing for the ATM gene is unlikely to be useful for predicting clinical response to radiotherapy in breast cancerpatients.
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