Literature DB >> 9682161

Determination of total cysteamine in human serum by a high-performance liquid chromatography with fluorescence detection.

M Stachowicz1, B Lehmann, A Tibi, P Prognon, V Daurat, D Pradeau.   

Abstract

A convenient, reliable and rapid method for determination of total cysteamine in human plasma by high-performance liquid chromatography with fluorescence detection is reported. This assay involves reduction of samples with dithiothreitol, derivatization of total cysteamine by addition of monobromobimane and protein precipitation by perchloric acid. The calibration curve was linear in the range 2-150 nmol ml-1 and the detection limit was 0.5 nmol ml-1. This method was successfully applied for a pharmacokinetic study of three cysteamine derivatives in healthy volunteers without any interference from coexisting substances.

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Year:  1998        PMID： 9682161     DOI： 10.1016/s0731-7085(97)00248-3

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  4 in total

1.  A study of the relative bioavailability of cysteamine hydrochloride, cysteamine bitartrate and phosphocysteamine in healthy adult male volunteers.

Authors:  L Tennezé; V Daurat; A Tibi; P Chaumet-Riffaud; C Funck-Brentano
Journal:  Br J Clin Pharmacol       Date:  1999-01       Impact factor: 4.335

2.  Steady-state pharmacokinetics and pharmacodynamics of cysteamine bitartrate in paediatric nephropathic cystinosis patients.

Authors:  Eric B Belldina; Mei Y Huang; Jerry A Schneider; Richard C Brundage; Timothy S Tracy
Journal:  Br J Clin Pharmacol       Date:  2003-11       Impact factor: 4.335

3.  Population pharmacokinetics and pharmacodynamics of cysteamine in nephropathic cystinosis patients.

Authors:  Naïm Bouazza; Jean-Marc Tréluyer; Chris Ottolenghi; Saik Urien; Georges Deschenes; Daniel Ricquier; Patrick Niaudet; Bernadette Chadefaux-Vekemans
Journal:  Orphanet J Rare Dis       Date:  2011-12-23       Impact factor: 4.123

4.  Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner.

Authors:  Palak J Trivedi; Joseph Tickle; Mette Nåmdal Vesterhus; Peter J Eddowes; Tony Bruns; Jani Vainio; Richard Parker; David Smith; Evaggelia Liaskou; Liv Wenche Thorbjørnsen; Gideon M Hirschfield; Kaisa Auvinen; Stefan G Hubscher; Marko Salmi; David H Adams; Chris J Weston
Journal:  Gut       Date:  2017-04-20       Impact factor: 23.059
  4 in total

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