Literature DB >> 9681521

Potential role of maternal progesterone in the sexual differentiation of the brain.

C K Wagner1, A Y Nakayama, G J De Vries.   

Abstract

In rats, fetal testosterone directs sexual differentiation of the brain. However, fetuses are also exposed to maternal progesterone. Here we report that progestin receptor immunoreactivity in the medial preoptic nucleus (MPN) of fetal and neonatal rats is high in males but virtually absent in females. The MPN is one of the most sexually dimorphic structures in the rat brain and mediates several sexually differentiated behaviors. This suggests that progesterone may play a previously overlooked role in the development of sex differences in the brain and behavior. Henceforth, a novel function of the mother in the sexual differentiation of the CNS must be considered.

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Year:  1998        PMID： 9681521     DOI： 10.1210/endo.139.8.6223

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  29 in total

Review 1.  Of mice and rats: key species variations in the sexual differentiation of brain and behavior.

Authors:  P J Bonthuis; K H Cox; B T Searcy; P Kumar; S Tobet; E F Rissman
Journal:  Front Neuroendocrinol       Date:  2010-05-10       Impact factor: 8.606

2.  Two-hit exposure to polychlorinated biphenyls at gestational and juvenile life stages: 2. Sex-specific neuromolecular effects in the brain.

Authors:  Margaret R Bell; Bethany G Hart; Andrea C Gore
Journal:  Mol Cell Endocrinol       Date:  2015-11-24       Impact factor: 4.102

3.  Differential control of sex differences in estrogen receptor α in the bed nucleus of the stria terminalis and anteroventral periventricular nucleus.

Authors:  D A Kelly; M M Varnum; A A Krentzel; S Krug; N G Forger
Journal:  Endocrinology       Date:  2013-09-11       Impact factor: 4.736

4.  Effects of prenatal stress on the activity of an enzyme involved in neurosteroid synthesis during the "critical period" of sexual differentiation of the brain in male rats.

Authors:  N E Ordyan; S G Pivina
Journal:  Neurosci Behav Physiol       Date:  2005-11

Review 5.  Progestin receptor subtypes in the brain: the known and the unknown.

Authors:  Shaila Mani
Journal:  Endocrinology       Date:  2008-02-28       Impact factor: 4.736

6.  The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats.

Authors:  Rebecca M Steinberg; Thomas E Juenger; Andrea C Gore
Journal:  Horm Behav       Date:  2006-12-22       Impact factor: 3.587

7.  Absence of progestin receptors alters distribution of vasopressin fibers but not sexual differentiation of vasopressin system in mice.

Authors:  B D Rood; E K Murray; J Laroche; M K Yang; J D Blaustein; G J De Vries
Journal:  Neuroscience       Date:  2008-06-26       Impact factor: 3.590

8.  Bisphenol A (BPA) induces progesterone receptor expression in an estrogen receptor α-dependent manner in perinatal brain.

Authors:  Allyssa Fahrenkopf; Christine K Wagner
Journal:  Neurotoxicol Teratol       Date:  2020-01-09       Impact factor: 3.763

9.  Anatomically-specific actions of oestrogen receptor in the developing female rat brain: effects of oestradiol and selective oestrogen receptor modulators on progestin receptor expression.

Authors:  K L Gonzales; P Quadros-Mennella; M J Tetel; C K Wagner
Journal:  J Neuroendocrinol       Date:  2012-02       Impact factor: 3.627

Review 10.  The neurobiology of sexual partner preferences in rams.

Authors:  Charles E Roselli; Fred Stormshak
Journal:  Horm Behav       Date:  2009-05       Impact factor: 3.587
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