OBJECTIVE: To assess the effect of alpha-tocopherol and beta-carotene supplementation on the prevalence of oral mucosal lesions in smokers. DESIGN: An end-point examination of a random sample of participants in a controlled trial for 5-7 years (Alpha-Tocopherol Beta-Carotene Cancer Prevention Study) in Helsinki, Finland. SUBJECTS: A total of 409 white male cigarette smokers, aged 55-74 years who received eitheralpha-tocopherol (50 mg per day) or beta-carotene (20 mg per day) supplementation, both of these or placebo capsules. METHODS: Clinical examination of oral mucosae, histological examination of lesions showing leukoplakia and cytological examination of buccal epithelium. Statistical analysis using Fisher's exact test. RESULTS: No statistically significant differences were found between the study groups either in the prevalence of oral mucosal lesions or in the cells of unkeratinized epithelium. Leukoplakia was present in 24 (5.9%) of the subjects. Seven lesions showed dysplasia. CONCLUSION: The present study on oral health does not support the hypothesis that alpha-tocopherol or beta-carotene supplementation plays an essential role in preventing oral mucosal changes in smokers.
RCT Entities:
OBJECTIVE: To assess the effect of alpha-tocopherol and beta-carotene supplementation on the prevalence of oral mucosal lesions in smokers. DESIGN: An end-point examination of a random sample of participants in a controlled trial for 5-7 years (Alpha-TocopherolBeta-Carotene Cancer Prevention Study) in Helsinki, Finland. SUBJECTS: A total of 409 white male cigarette smokers, aged 55-74 years who received either alpha-tocopherol (50 mg per day) or beta-carotene (20 mg per day) supplementation, both of these or placebo capsules. METHODS: Clinical examination of oral mucosae, histological examination of lesions showing leukoplakia and cytological examination of buccal epithelium. Statistical analysis using Fisher's exact test. RESULTS: No statistically significant differences were found between the study groups either in the prevalence of oral mucosal lesions or in the cells of unkeratinized epithelium. Leukoplakia was present in 24 (5.9%) of the subjects. Seven lesions showed dysplasia. CONCLUSION: The present study on oral health does not support the hypothesis that alpha-tocopherol or beta-carotene supplementation plays an essential role in preventing oral mucosal changes in smokers.
Authors: Charles M Rudin; Ezra E W Cohen; Vassiliki A Papadimitrakopoulou; Sol Silverman; Wendy Recant; Adel K El-Naggar; Kirsten Stenson; Scott M Lippman; Waun Ki Hong; Everett E Vokes Journal: J Clin Oncol Date: 2003-11-03 Impact factor: 44.544
Authors: P D Karkos; S C Leong; C D Karkos; N Sivaji; D A Assimakopoulos Journal: Evid Based Complement Alternat Med Date: 2010-10-19 Impact factor: 2.629