| Literature DB >> 9680380 |
K Opdecamp1, P Vanvooren, M Rivière, H Arnheiter, R Motta, J Szpirer, C Szpirer.
Abstract
The rat gene encoding the microphthalmia-associated transcription factor (Mitf) was assigned to rat Chromosome (Chr) 4q34-q41, as well as the Gata2 and Mem1 genes. Rat Chr 4 is homologous to mouse Chr 6 and human Chr 3, which carry the Mitf (MITF) gene in these species (MMU 6, 40.0 cM, and HSA 3p14.1-p12.3). mib/mib rats, which are characterized by depigmentation, microphtalmy, osteopetrosis, and neurological disorders were shown to bear a deletion covering several kilobases of genomic DNA in the Mitf gene and to lack Mitf mRNA. The Mitf mutation in the mib/mib rats is thus very likely to be a Mitf null mutation, causing a phenotype similar to the one observed in the miVGA-9 mice, but including osteopetrosis as an additional feature.Entities:
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Year: 1998 PMID： 9680380 DOI： 10.1007/s003359900832
Source DB: PubMed Journal: Mamm Genome ISSN： 0938-8990 Impact factor: 2.957