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Literature DB >> 9679060

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation.

Abstract

Smads regulate transcription of defined genes in response to TGF-beta receptor activation, although the mechanisms of Smad-mediated transcription are not well understood. We demonstrate that the TGF-beta-inducible Smad3 uses the tumor suppressor Smad4/DPC4 and CBP/p300 as transcriptional coactivators, which associate with Smad3 in response to TGF-beta. The association of CBP with Smad3 was localized to the carboxyl terminus of Smad3, which is required for transcriptional activation, and a defined segment in CBP. Furthermore, CBP/p300 stimulated both TGF-beta- and Smad-induced transcription in a Smad4/DPC4-dependent fashion. Smad3 transactivation and TGF-beta-induced transcription were inhibited by expressing E1A, which interferes with CBP functions. The coactivator functions and physical interactions of Smad4 and CBP/p300 with Smad3 allow a model for the induction of gene expression in response to TGF-beta.

Entities: Disease Gene

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Year: 1998 PMID： 9679060 PMCID： PMC317015 DOI： 10.1101/gad.12.14.2153

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

41 in total

1. Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains.

Authors: V B Kraus; E Moran; J R Nevins
Journal: Mol Cell Biol Date: 1992-10 Impact factor: 4.272

2. Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling.

Authors: S Souchelnytskyi; K Tamaki; U Engström; C Wernstedt; P ten Dijke; C H Heldin
Journal: J Biol Chem Date: 1997-10-31 Impact factor: 5.157

3. Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300.

Authors: A E Horvai; L Xu; E Korzus; G Brard; D Kalafus; T M Mullen; D W Rose; M G Rosenfeld; C K Glass
Journal: Proc Natl Acad Sci U S A Date: 1997-02-18 Impact factor: 11.205

Review 4. The multifunctional role of the co-activator CBP in transcriptional regulation.

Authors: P S Goldman; V K Tran; R H Goodman
Journal: Recent Prog Horm Res Date: 1997

5. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.

Authors: Y Zhang; X Feng; R We; R Derynck
Journal: Nature Date: 1996-09-12 Impact factor: 49.962

6. A structural basis for mutational inactivation of the tumour suppressor Smad4.

Authors: Y Shi; A Hata; R S Lo; J Massagué; N P Pavletich
Journal: Nature Date: 1997-07-03 Impact factor: 49.962

7. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

Authors: G Lagna; A Hata; A Hemmati-Brivanlou; J Massagué
Journal: Nature Date: 1996-10-31 Impact factor: 49.962

8. The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function.

Authors: Y Zhang; T Musci; R Derynck
Journal: Curr Biol Date: 1997-04-01 Impact factor: 10.834

Review 9. TGF-beta signalling from cell membrane to nucleus through SMAD proteins.

Authors: C H Heldin; K Miyazono; P ten Dijke
Journal: Nature Date: 1997-12-04 Impact factor: 49.962

10. Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors.

Authors: X H Feng; E H Filvaroff; R Derynck
Journal: J Biol Chem Date: 1995-10-13 Impact factor: 5.157

135 in total

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation.

1. Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains.

2. Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling.

3. Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300.

Review 4. The multifunctional role of the co-activator CBP in transcriptional regulation.

5. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.

6. A structural basis for mutational inactivation of the tumour suppressor Smad4.

7. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

8. The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function.

Review 9. TGF-beta signalling from cell membrane to nucleus through SMAD proteins.

10. Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors.

1. Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.

Review 2. Transcriptional control by the TGF-beta/Smad signaling system.

3. A function of CBP as a transcriptional co-activator during Dpp signalling.

4. A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.

5. TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3.

6. Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling.

7. Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB.

8. Tissue- and stage-specific modulation of Wingless signaling by the segment polarity gene lines.

Review 9. TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis.

10. Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling.