| Literature DB >> 9677271 |
A H Banskota1, Y Tezuka, J K Prasain, K Matsushige, I Saiki, S Kadota.
Abstract
The EtOAc-soluble fraction of the MeOH extract of propolis afforded a new prenylated chromane derivative, 3-hydroxy-2, 2-dimethyl-8-prenylchromane-6-propenoic acid (1), along with 22 known compounds, 2-23. Of the known compounds, 4, 7, 12-19, and 22 were isolated for the first time from propolis, and the absolute configuration of 23 was established as (2S,3R). Investigation suggested that Baccharis spp. are a significant source of tropical Brazilian propolis, in addition to Clusia minor, Clusia major, and Araucaria heterophylla. All the compounds were tested for their cytotoxicity toward human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells. Among these compounds, 9 and 19-21 showed potent cytotoxicity, having ED50 values equal to or less than 10 microg/mL.Entities:
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Year: 1998 PMID： 9677271 DOI： 10.1021/np980028c
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050