Literature DB >> 9677199

A viral mechanism for inhibition of the cellular phosphatase calcineurin.

J E Miskin1, C C Abrams, L C Goatley, L K Dixon.   

Abstract

The transcription factor NFAT (nuclear factor of activated T cells) controls the expression of many immunomodulatory proteins. African swine fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-regulated gene transcription in vivo. This it does by binding the catalytic subunit of calcineurin and inhibiting calcineurin phosphatase activity.

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Year:  1998        PMID： 9677199     DOI： 10.1126/science.281.5376.562

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  45 in total

1.  Two distinct action mechanisms of immunophilin-ligand complexes for the blockade of T-cell activation.

Authors:  S Matsuda; F Shibasaki; K Takehana; H Mori; E Nishida; S Koyasu
Journal:  EMBO Rep       Date:  2000-11       Impact factor: 8.807

2.  Nuclear translocation and activation of the transcription factor NFAT is blocked by herpes simplex virus infection.

Authors:  E S Scott; S Malcomber; P O'Hare
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

3.  Evolutionary relationships among Rel domains indicate functional diversification by recombination.

Authors:  I A Graef; J M Gastier; U Francke; G R Crabtree
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-08       Impact factor: 11.205

4.  African swine fever virus protein A238L interacts with the cellular phosphatase calcineurin via a binding domain similar to that of NFAT.

Authors:  J E Miskin; C C Abrams; L K Dixon
Journal:  J Virol       Date:  2000-10       Impact factor: 5.103

5.  Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma.

Authors:  D Sampath; M Castro; D C Look; M J Holtzman
Journal:  J Clin Invest       Date:  1999-05       Impact factor: 14.808

Review 6.  The role of serine/threonine protein phosphatases in exocytosis.

Authors:  Alistair T R Sim; Monique L Baldwin; John A P Rostas; Jeff Holst; Russell I Ludowyke
Journal:  Biochem J       Date:  2003-08-01       Impact factor: 3.857

7.  Inhibition of interleukin-2 gene expression by human herpesvirus 6B U54 tegument protein.

Authors:  Mathieu Iampietro; Guillaume Morissette; Annie Gravel; Louis Flamand
Journal:  J Virol       Date:  2014-08-13       Impact factor: 5.103

8.  The African swine fever virus protein j4R binds to the alpha chain of nascent polypeptide-associated complex.

Authors:  Lynnette C Goatley; Steve R F Twigg; James E Miskin; Paul Monaghan; René St-Arnaud; Geoffrey L Smith; Linda K Dixon
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

9.  Modulation of p53 cellular function and cell death by African swine fever virus.

Authors:  Aitor G Granja; María L Nogal; Carolina Hurtado; José Salas; María L Salas; Angel L Carrascosa; Yolanda Revilla
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

10.  Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?

Authors:  Matthias Sieber; Ria Baumgrass
Journal:  Cell Commun Signal       Date:  2009-10-27       Impact factor: 5.712
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