PURPOSE: The purpose of this study was to compare the response in contractility of the right (RV) and left (LV) ventricle of the heart to beta-adrenergic stimulation using an echo planar MR technique. METHOD: In six sheep, RV and LV pressure-volume (P-V) relationships were constructed simultaneously using intraventricular pressures and volumes measured with echo planar MRI at rest and during dobutamine stress. Contractility changes were quantified by assessment of the end-systolic P-V relationship (ESPVR) and the preload recruitable stroke work (PRSW). RESULTS: Both the ESPVR the the PRSW showed a significant increase in contractility for both ventricles after dobutamine administration. The increase in contractility was significantly larger for the LV than for the RV, both measured wit the ESPVR (p < 0.0003) and the PRSW (p < 0.007). CONCLUSION: This study shows the usefulness of echo planar MRI to assess myocardial contractility of both ventricles simultaneously. Furthermore, the study shows that beta-adrenergic stimulation has a significantly greater positive inotropic effect on LV contractility than on RV contractility.
PURPOSE: The purpose of this study was to compare the response in contractility of the right (RV) and left (LV) ventricle of the heart to beta-adrenergic stimulation using an echo planar MR technique. METHOD: In six sheep, RV and LV pressure-volume (P-V) relationships were constructed simultaneously using intraventricular pressures and volumes measured with echo planar MRI at rest and during dobutamine stress. Contractility changes were quantified by assessment of the end-systolic P-V relationship (ESPVR) and the preload recruitable stroke work (PRSW). RESULTS: Both the ESPVR the the PRSW showed a significant increase in contractility for both ventricles after dobutamine administration. The increase in contractility was significantly larger for the LV than for the RV, both measured wit the ESPVR (p < 0.0003) and the PRSW (p < 0.007). CONCLUSION: This study shows the usefulness of echo planar MRI to assess myocardial contractility of both ventricles simultaneously. Furthermore, the study shows that beta-adrenergic stimulation has a significantly greater positive inotropic effect on LV contractility than on RV contractility.
Authors: I I Tulevski; H Romkes; A Dodge-Khatami; E E van der Wall; M Groenink; D J van Veldhuisen; B J M Mulder Journal: Int J Cardiovasc Imaging Date: 2002-02 Impact factor: 2.357
Authors: I I Tulevski; P L Lee; M Groenink; E E van der Wall; J Stoker; P G Pieper; H Romkes; A Hirsch; B J Mulder Journal: Int J Card Imaging Date: 2000-12
Authors: Walter R T Witschey; Francisco Contijoch; Jeremy R McGarvey; Victor A Ferrari; Michael S Hansen; Madonna E Lee; Satoshi Takebayashi; Chikashi Aoki; Julio A Chirinos; Paul A Yushkevich; Joseph H Gorman; James J Pilla; Robert C Gorman Journal: Ann Thorac Surg Date: 2014-03-12 Impact factor: 4.330