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Literature DB >> 9675240

Multiple antimutagenesis mechanisms affect mutagenic activity and specificity of the base analog 6-N-hydroxylaminopurine in bacteria and yeast.

S G Kozmin¹, R M Schaaper, P V Shcherbakova, V N Kulikov, V N Noskov, M L Guetsova, V V Alenin, I B Rogozin, K S Makarova, Y I Pavlov.

Abstract

Base analog 6-N-hydroxylaminopurine is a potent mutagen in variety of prokaryotic and eukaryotic organisms. In the review, we discuss recent results of the studies of HAP mutagenic activity, genetic control and specificity in bacteria and yeast with the emphasis to the mechanisms protecting living cells from mutagenic and toxic effects of this base analog. Copyright 1998 Elsevier Science B.V. All rights reserved.

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Year: 1998 PMID： 9675240 DOI： 10.1016/s0027-5107(97)00280-7

Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433

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Cited

26 in total

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3. The twists and turns of enzyme function.

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Review 4. Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.

Authors: Irina S-R Waisertreiger; Victoria G Liston; Miriam R Menezes; Hyun-Min Kim; Kirill S Lobachev; Elena I Stepchenkova; Tahir H Tahirov; Igor B Rogozin; Youri I Pavlov
Journal: Environ Mol Mutagen Date: 2012-10-10 Impact factor: 3.216

5. Hypersensitivity of Escherichia coli Delta(uvrB-bio) mutants to 6-hydroxylaminopurine and other base analogs is due to a defect in molybdenum cofactor biosynthesis.

Authors: S G Kozmin; Y I Pavlov; R L Dunn; R M Schaaper
Journal: J Bacteriol Date: 2000-06 Impact factor: 3.490

Multiple antimutagenesis mechanisms affect mutagenic activity and specificity of the base analog 6-N-hydroxylaminopurine in bacteria and yeast.

1. Mechanism of Action of the Cytotoxic Asmarine Alkaloids.

2. Functional study of the P32T ITPA variant associated with drug sensitivity in humans.

3. The twists and turns of enzyme function.

Review 4. Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.

5. Hypersensitivity of Escherichia coli Delta(uvrB-bio) mutants to 6-hydroxylaminopurine and other base analogs is due to a defect in molybdenum cofactor biosynthesis.

6. Structure of the orthorhombic form of human inosine triphosphate pyrophosphatase.

7. Repair system for noncanonical purines in Escherichia coli.

8. Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways.

9. Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA Variant.

10. Production of clastogenic DNA precursors by the nucleotide metabolism in Escherichia coli.