Literature DB >> 9675117

Release of telomeric DNA from chromosomes in immortal human cells lacking telomerase activity.

H Ogino1, K Nakabayashi, M Suzuki, E Takahashi, M Fujii, T Suzuki, D Ayusawa.   

Abstract

Some immortal human cell lines lack telomerase activity. These cell lines were found to contain small dispersed DNA hybridizing to TTAGGG repeats. Such DNA was located in their cytoplasm and nuclei. Normal human fibroblasts or telomerase-positive cell lines did not contain such DNA. Upon cloning and sequencing, it was shown to consist of TTAGGG repeats. When electrophoresed on neutral and alkaline agarose gels, it behaved as double-stranded and linear DNA. These results suggest that telomeric DNA is released from chromosomes in association with maintenance of telomeres in telomerase-negative cell lines. Copyright 1998 Academic Press.

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Year:  1998        PMID： 9675117     DOI： 10.1006/bbrc.1998.8875

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  24 in total

1.  Telomere repeat DNA forms a large non-covalent complex with unique cohesive properties which is dissociated by Werner syndrome DNA helicase in the presence of replication protein A.

Authors:  I Ohsugi; Y Tokutake; N Suzuki; T Ide; M Sugimoto; Y Furuichi
Journal:  Nucleic Acids Res       Date:  2000-09-15       Impact factor: 16.971

2.  Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops.

Authors:  Anthony J Cesare; Jack D Griffith
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

3.  Mutant telomeric repeats in yeast can disrupt the negative regulation of recombination-mediated telomere maintenance and create an alternative lengthening of telomeres-like phenotype.

Authors:  Laura H Bechard; Bilge D Butuner; George J Peterson; Will McRae; Zeki Topcu; Michael J McEachern
Journal:  Mol Cell Biol       Date:  2008-11-24       Impact factor: 4.272

4.  Unusual telomeric DNAs in human telomerase-negative immortalized cells.

Authors:  Akira Nabetani; Fuyuki Ishikawa
Journal:  Mol Cell Biol       Date:  2008-11-17       Impact factor: 4.272

5.  Inter-telomeric recombination is present in telomerase-positive human cells.

Authors:  Margit Dlaska; Patrick Schöffski; Oliver E Bechter
Journal:  Cell Cycle       Date:  2013-06-06       Impact factor: 4.534

6.  Differential requirements for DNA repair proteins in immortalized cell lines using alternative lengthening of telomere mechanisms.

Authors:  Alaina R Martinez; Zeenia Kaul; Jeffrey D Parvin; Joanna Groden
Journal:  Genes Chromosomes Cancer       Date:  2017-05-31       Impact factor: 5.006

Review 7.  Alternative lengthening of telomeres: models, mechanisms and implications.

Authors:  Anthony J Cesare; Roger R Reddel
Journal:  Nat Rev Genet       Date:  2010-03-30       Impact factor: 53.242

8.  5' C-rich telomeric overhangs are an outcome of rapid telomere truncation events.

Authors:  Liana Oganesian; Jan Karlseder
Journal:  DNA Repair (Amst)       Date:  2013-01-21

9.  Recombination and its roles in DNA repair, cellular immortalization and cancer.

Authors:  M A Shammas; R J Shmookler Reis
Journal:  Age (Omaha)       Date:  1999-04

10.  Cell proliferation in the presence of telomerase.

Authors:  Krastan B Blagoev
Journal:  PLoS One       Date:  2009-02-27       Impact factor: 3.240
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