Literature DB >> 9673292

Binding of the Helicobacter pylori vacuolating cytotoxin to target cells.

P Massari1, R Manetti, D Burroni, S Nuti, N Norais, R Rappuoli, J L Telford.   

Abstract

The vacuolating cytotoxin of Helicobacter pylori, VacA, enters the cytoplasm of target cells and causes vacuolar degeneration by interfering with late stages of endocytosis. By using indirect immunofluorescence and flow cytometry, we have demonstrated that VacA binds to specific high-affinity cell surface receptors and that this interaction is necessary for cell intoxication.

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Year:  1998        PMID： 9673292      PMCID： PMC108470     

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  11 in total

Review 1.  Molecular mechanisms of action of bacterial exotoxins.

Authors:  J Balfanz; P Rautenberg; U Ullmann
Journal:  Zentralbl Bakteriol       Date:  1996-07

2.  Helicobacter pylori toxin VacA induces vacuole formation by acting in the cell cytosol.

Authors:  M de Bernard; B Arico; E Papini; R Rizzuto; G Grandi; R Rappuoli; C Montecucco
Journal:  Mol Microbiol       Date:  1997-11       Impact factor: 3.501

3.  Three-dimensional reconstruction of metal replicas of the Helicobacter pylori vacuolating cytotoxin.

Authors:  S Lanzavecchia; P L Bellon; P Lupetti; R Dallai; R Rappuoli; J L Telford
Journal:  J Struct Biol       Date:  1998-01       Impact factor: 2.867

4.  Binding and internalization of the Helicobacter pylori vacuolating cytotoxin by epithelial cells.

Authors:  J A Garner; T L Cover
Journal:  Infect Immun       Date:  1996-10       Impact factor: 3.441

5.  Helicobacter pylori vacuolating cytotoxin binds to the 140-kDa protein in human gastric cancer cell lines, AZ-521 and AGS.

Authors:  K Yahiro; T Niidome; T Hatakeyama; H Aoyagi; H Kurazono; P I Padilla; A Wada; T Hirayama
Journal:  Biochem Biophys Res Commun       Date:  1997-09-18       Impact factor: 3.575

6.  Detoxification of the Helicobacter pylori cytotoxin.

Authors:  R Manetti; P Massari; M Marchetti; C Magagnoli; S Nuti; P Lupetti; P Ghiara; R Rappuoli; J L Telford
Journal:  Infect Immun       Date:  1997-11       Impact factor: 3.441

7.  Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant.

Authors:  M de Bernard; E Papini; V de Filippis; E Gottardi; J Telford; R Manetti; A Fontana; R Rappuoli; C Montecucco
Journal:  J Biol Chem       Date:  1995-10-13       Impact factor: 5.157

8.  Helicobacter pylori cytotoxin: importance of native conformation for induction of neutralizing antibodies.

Authors:  R Manetti; P Massari; D Burroni; M de Bernard; A Marchini; R Olivieri; E Papini; C Montecucco; R Rappuoli; J L Telford
Journal:  Infect Immun       Date:  1995-11       Impact factor: 3.441

9.  Bafilomycin A1 inhibits Helicobacter pylori-induced vacuolization of HeLa cells.

Authors:  E Papini; M Bugnoli; M De Bernard; N Figura; R Rappuoli; C Montecucco
Journal:  Mol Microbiol       Date:  1993-01       Impact factor: 3.501

10.  Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly.

Authors:  T L Cover; P I Hanson; J E Heuser
Journal:  J Cell Biol       Date:  1997-08-25       Impact factor: 10.539
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  18 in total

1.  How the loop and middle regions influence the properties of Helicobacter pylori VacA channels.

Authors:  F Tombola; C Pagliaccia; S Campello; J L Telford; C Montecucco; E Papini; M Zoratti
Journal:  Biophys J       Date:  2001-12       Impact factor: 4.033

2.  Plasma membrane cholesterol modulates cellular vacuolation induced by the Helicobacter pylori vacuolating cytotoxin.

Authors:  Hetal K Patel; David C Willhite; Rakhi M Patel; Dan Ye; Christopher L Williams; Eric M Torres; Kent B Marty; Robert A MacDonald; Steven R Blanke
Journal:  Infect Immun       Date:  2002-08       Impact factor: 3.441

3.  The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH.

Authors:  D M Czajkowsky; H Iwamoto; T L Cover; Z Shao
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

4.  The cell-specific phenotype of the polymorphic vacA midregion is independent of the appearance of the cell surface receptor protein tyrosine phosphatase beta.

Authors:  David A G Skibinski; Christophe Genisset; Silvia Barone; John L Telford
Journal:  Infect Immun       Date:  2006-01       Impact factor: 3.441

5.  The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release.

Authors:  A Galmiche; J Rassow; A Doye; S Cagnol; J C Chambard; S Contamin; V de Thillot; I Just; V Ricci; E Solcia; E Van Obberghen; P Boquet
Journal:  EMBO J       Date:  2000-12-01       Impact factor: 11.598

6.  Determinants of Raft Partitioning of the Helicobacter pylori Pore-Forming Toxin VacA.

Authors:  Krishnan Raghunathan; Nora J Foegeding; Anne M Campbell; Timothy L Cover; Melanie D Ohi; Anne K Kenworthy
Journal:  Infect Immun       Date:  2018-04-23       Impact factor: 3.441

7.  Resistance of primary murine CD4+ T cells to Helicobacter pylori vacuolating cytotoxin.

Authors:  Holly M Scott Algood; Victor J Torres; Derya Unutmaz; Timothy L Cover
Journal:  Infect Immun       Date:  2006-10-30       Impact factor: 3.441

8.  Deletion of Helicobacter pylori vacuolating cytotoxin gene by introduction of directed mutagenesis.

Authors:  Jian-Ping Yuan; Tao Li; Xiao-Dong Shi; Bao-Yu Hu; Gui-Zhen Yang; Shan-Qing Tong; Xiao-Kui Guo
Journal:  World J Gastroenterol       Date:  2003-10       Impact factor: 5.742

9.  Helicobacter pylori outer membrane vesicles modulate proliferation and interleukin-8 production by gastric epithelial cells.

Authors:  Salim Ismail; Mark B Hampton; Jacqueline I Keenan
Journal:  Infect Immun       Date:  2003-10       Impact factor: 3.441

10.  Helicobacter pylori tumor necrosis factor-α inducing protein promotes cytokine expression via nuclear factor-κB.

Authors:  Chun-Li Tang; Bo Hao; Guo-Xin Zhang; Rui-Hua Shi; Wen-Fang Cheng
Journal:  World J Gastroenterol       Date:  2013-01-21       Impact factor: 5.742
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