Activation of c-jun and c-fos genes in dNTP imbalance cell death induced with 5-fluoro-2'-deoxyuridine in mouse mammary tumor FM3A cell line.

5-Fluoro-2' -deoxyuridine (FdUrd)-induced death of mouse mammary FM3A cells was found to be associated with an increased expression of cellular c-jun and c-fos genes. The increase in these gene expressions was mediated through the protein kinase C-dependent pathway. Blockage of the expressions with the use of antisense oligodeoxynucleotide for c-jun delayed the cell death. These findings suggest that the activation of c-jun and c-fos genes, which encode transcription factors participating in cell proliferation, plays a role in FdUrd-induced cell death.