Literature DB >> 9672240

The renal type II Na+/phosphate cotransporter.

J Biber1, H Murer, I Forster.   

Abstract

A sodium-dependent phosphate transporter (type II Na/Pi-cotransporter) was isolated which is expressed in apical membranes of proximal tubules and exhibits transport characteristics similar as described for renal reabsorption of phosphate. Type II associated Na/Pi-cotransport is electrogenic and results obtained by electrophysiological measurements support a transport model having a stoichiometry of 3 Na+/HPO4=. Changes of transport such as by parathyroid hormone and altered dietary intake of phosphate correlate with changes of the number of type II cotransporters in the apical membrane. These data suggest that the type II Na/Pi-cotransporter represents the main target for physiological and pathophysiological regulation.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9672240     DOI： 10.1023/a:1020525409894

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   2.945


  37 in total

1.  Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores.

Authors:  M S Marks; H Ohno; T Kirchnausen; J S Bonracino
Journal:  Trends Cell Biol       Date:  1997-03       Impact factor: 20.808

2.  Expression of Na-P(i) cotransport in rat kidney: localization by RT-PCR and immunohistochemistry.

Authors:  M Custer; M Lötscher; J Biber; H Murer; B Kaissling
Journal:  Am J Physiol       Date:  1994-05

Review 3.  Renal Na/Pi-cotransporters.

Authors:  J Biber; M Custer; S Magagnin; G Hayes; A Werner; M Lötscher; B Kaissling; H Murer
Journal:  Kidney Int       Date:  1996-04       Impact factor: 10.612

Review 4.  Identification and characterization of a widely expressed phosphate transporter/retrovirus receptor family.

Authors:  M P Kavanaugh; D Kabat
Journal:  Kidney Int       Date:  1996-04       Impact factor: 10.612

5.  Phosphate transport by isolated renal brush border vesicles.

Authors:  N Hoffmann; M Thees; R Kinne
Journal:  Pflugers Arch       Date:  1976-03-30       Impact factor: 3.657

6.  Transport characteristics of a murine renal Na/Pi-cotransporter.

Authors:  C M Hartmann; C A Wagner; A E Busch; D Markovich; J Biber; F Lang; H Murer
Journal:  Pflugers Arch       Date:  1995-09       Impact factor: 3.657

7.  Parathyroid hormone-dependent degradation of type II Na+/Pi cotransporters.

Authors:  M F Pfister; E Lederer; J Forgo; U Ziegler; M Lötscher; E S Quabius; J Biber; H Murer
Journal:  J Biol Chem       Date:  1997-08-08       Impact factor: 5.157

8.  Cloning of a rabbit renal Na-Pi cotransporter, which is regulated by dietary phosphate.

Authors:  T Verri; D Markovich; C Perego; F Norbis; G Stange; V Sorribas; J Biber; H Murer
Journal:  Am J Physiol       Date:  1995-04

Review 9.  Sodium cotransporters.

Authors:  E M Wright; D D Loo; E Turk; B A Hirayama
Journal:  Curr Opin Cell Biol       Date:  1996-08       Impact factor: 8.382

10.  Molecular cloning, functional expression, tissue distribution, and in situ hybridization of the renal sodium phosphate (Na+/P(i)) transporter in the control and hypophosphatemic mouse.

Authors:  J F Collins; F K Ghishan
Journal:  FASEB J       Date:  1994-08       Impact factor: 5.191
View more
  5 in total

1.  Role of anion-cation interactions on the pre-steady-state currents of the rat Na(+)-Cl(-)-dependent GABA cotransporter rGAT1.

Authors:  Elena Bossi; Stefano Giovannardi; Francesca Binda; Greta Forlani; Antonio Peres
Journal:  J Physiol       Date:  2002-06-01       Impact factor: 5.182

2.  Profiling of renal tubule Na+ transporter abundances in NHE3 and NCC null mice using targeted proteomics.

Authors:  H L Brooks; A M Sorensen; J Terris; P J Schultheis; J N Lorenz; G E Shull; M A Knepper
Journal:  J Physiol       Date:  2001-02-01       Impact factor: 5.182

3.  Properties of the mutant Ser-460-Cys implicate this site in a functionally important region of the type IIa Na(+)/P(i) cotransporter protein.

Authors:  G Lambert; I C Forster; G Stange; J Biber; H Murer
Journal:  J Gen Physiol       Date:  1999-11       Impact factor: 4.086

4.  Growth, immortalization, and differentiation potential of normal adult human proximal tubule cells.

Authors:  David E Orosz; Philip G Woost; Robert J Kolb; Margaret B Finesilver; Wenwu Jin; Phyllis S Frisa; Chee-Keong Choo; Chung-Fai Yau; Kwok-Wah Chan; Martin I Resnick; Janice G Douglas; John C Edwards; James W Jacobberger; Ulrich Hopfer
Journal:  In Vitro Cell Dev Biol Anim       Date:  2004 Jan-Feb       Impact factor: 2.416

5.  Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent.

Authors:  Theresa Berndt; Theodore A Craig; Ann E Bowe; John Vassiliadis; David Reczek; Richard Finnegan; Suzanne M Jan De Beur; Susan C Schiavi; Rajiv Kumar
Journal:  J Clin Invest       Date:  2003-09       Impact factor: 14.808
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.