Literature DB >> 967188

Cytogenetic effects of mutagens/carcinogens after activation in a microsomal system in vitro I. Induction of chromosome aberrations and sister chromatid exchanges by diethylnitrosamine (DEN) and dimethylnitrosamine (DMN) in CHO cells in the presence of rat-liver microsomes.

A T Natarajan, A D Tates, P P Van Buul, M Meijers, N De Vogel.   

Abstract

A rat-liver microsomal system in vitro has been used to activate two indirectly acting carcinogens, DMN and DEN. On activation, both compounds were extremely potent in inducing chromosomal aberrations as well as sister chromatid exchanges in Chinese hamster cells. The implications of these findings and the potential utility of this technique to detect mutagens/carcinogens are discussed.

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Year:  1976        PMID： 967188     DOI： 10.1016/0027-5107(76)90057-9

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  12 in total

1.  Sister chromatid exchange in lymphocytes from patients with malignant lymphoma.

Authors:  K Kurvink; C D Bloomfield; K M Keenan; S Levitt; J Cervenka
Journal:  Hum Genet       Date:  1978-10-31       Impact factor: 4.132

2.  Activation of cyclophosphamide using perfused rat liver system and induction of sister chromatid exchanges in vitro.

Authors:  T Abe; T Ide; M Tosa; T Takahashi; T Takino
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

3.  Test systems for mutagenicity screening of environmental chemicals and their relevance for the evaluation of genetic hazards to man.

Authors:  K Sankaranarayanan
Journal:  J Cancer Res Clin Oncol       Date:  1981       Impact factor: 4.553

4.  Structure/activity investigations in eight arylalkyltriazenes comparison of chemical stability, mode of decomposition, and SCE induction in Chinese hamster V79-E cells.

Authors:  R Thust; M Schneider; U Wagner; D Schreiber
Journal:  Cell Biol Toxicol       Date:  1991-04       Impact factor: 6.691

5.  Reduced N-methyl-N'-nitro-N-nitrosoguanidine sister chromatid exchange induction in Chinese hamster V79 cells pre-exposed to 5-bromodeoxyuridine.

Authors:  N C Popescu; S A Amsbaugh; J A DiPaolo
Journal:  Chromosoma       Date:  1980       Impact factor: 4.316

Review 6.  Methods for analysis of the mutagenicity of indirect mutagens/carcinogens in eukaryotic cells.

Authors:  S Madle; G Obe
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

7.  Mutagenicity and chromosomal aberrations as an analytical tool for in vitro detection of mammalian enzyme-mediated formation of reactive metabolites.

Authors:  H Greim; D Bimboes; G Egert; W Göggelmann; M Krämer
Journal:  Arch Toxicol       Date:  1977-12-30       Impact factor: 5.153

8.  Enhancement of sister-chromatid exchanges by tumour promoters.

Authors:  R Ray-Chaudhuri; M Currens; P T Iype
Journal:  Br J Cancer       Date:  1982-05       Impact factor: 7.640

9.  Mutagenicity testing of diethylene glycol monobutyl ether.

Authors:  E D Thompson; W J Coppinger; R Valencia; J Iavicoli
Journal:  Environ Health Perspect       Date:  1984-08       Impact factor: 9.031

Review 10.  Effects of coal combustion products and metal compounds on sister chromatid exchange (SCE) in a macrophagelike cell line.

Authors:  O Andersen
Journal:  Environ Health Perspect       Date:  1983-01       Impact factor: 9.031
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