Literature DB >> 9671088

Clozapine and olanzapine treatment decreases rat cortical and limbic GABA(A) receptors.

D Farnbach-Pralong1, R Bradbury, D Copolov, B Dean.   

Abstract

The density of GABA(A) receptors in the hippocampus and the temporal cortex from rats treated for 28 days with either haloperidol, chlorpromazine, clozapine or olanzapine was measured. Compared to haloperidol (0.01 and 0.1 mg kg(-1) day(-1)) and chlorpromazine (0.1 and 1 mg kg(-1) day(-1)), clozapine and olanzapine (0.1 and 1 mg kg(-1) day(-1)) markedly decreased the density of GABA(A) receptors in these two brain regions. These data suggest that modulation of GABAergic transmission could be an important action of some antipsychotic drugs.

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Year:  1998        PMID： 9671088     DOI： 10.1016/s0014-2999(98)00285-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  15 in total

1.  Effect of antipsychotics on cortical inhibition using transcranial magnetic stimulation.

Authors:  Zafiris J Daskalakis; Bruce K Christensen; Robert Chen; Paul B Fitzgerald; Robert B Zipursky; Shitij Kapur
Journal:  Psychopharmacology (Berl)       Date:  2003-08-07       Impact factor: 4.530

2.  Increased density of GABAA receptors in the superior temporal gyrus in schizophrenia.

Authors:  Chao Deng; Xu-Feng Huang
Journal:  Exp Brain Res       Date:  2005-12-16       Impact factor: 1.972

Review 3.  Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection.

Authors:  Jeffrey A Lieberman; Frank P Bymaster; Herbert Y Meltzer; Ariel Y Deutch; Gary E Duncan; Christine E Marx; June R Aprille; Donard S Dwyer; Xin-Min Li; Sahebarao P Mahadik; Ronald S Duman; Joseph H Porter; Josephine S Modica-Napolitano; Samuel S Newton; John G Csernansky
Journal:  Pharmacol Rev       Date:  2008-09       Impact factor: 25.468

4.  Additivities of compounds that increase the numbers of high affinity [3H]muscimol binding sites by different amounts define more than 9 GABA(A) receptor complexes in rat forebrain: implications for schizophrenia and clozapine research.

Authors:  R F Squires; E Saederup
Journal:  Neurochem Res       Date:  2000-12       Impact factor: 3.996

5.  The effects of neuroleptics on the GABA-induced Cl- current in rat dorsal root ganglion neurons: differences between some neuroleptics.

Authors:  Kenjiro Yokota; Hideharu Tatebayashi; Tadashi Matsuo; Takashi Shoge; Haruhiko Motomura; Toshiyuki Matsuno; Akira Fukuda; Nobutada Tashiro
Journal:  Br J Pharmacol       Date:  2002-03       Impact factor: 8.739

6.  Developmental GABAergic deficit enhances methamphetamine-induced apoptosis.

Authors:  Tomohiro Abekawa; Koki Ito; Yasuya Nakato; Tsukasa Koyama
Journal:  Psychopharmacology (Berl)       Date:  2011-04-14       Impact factor: 4.530

7.  Different effects of isolation-rearing and neonatal MK-801 treatment on attentional modulations of prepulse inhibition of startle in rats.

Authors:  Zhe-Meng Wu; Yu Ding; Hong-Xiao Jia; Liang Li
Journal:  Psychopharmacology (Berl)       Date:  2016-07-01       Impact factor: 4.530

8.  Pregnenolone-progesterone-allopregnanolone pathway as a potential therapeutic target in first-episode antipsychotic-naïve patients with schizophrenia.

Authors:  HuaLin Cai; Xiang Zhou; George G Dougherty; Ravinder D Reddy; Gretchen L Haas; Debra M Montrose; Matcheri Keshavan; Jeffrey K Yao
Journal:  Psychoneuroendocrinology       Date:  2018-02-07       Impact factor: 4.905

9.  Clozapine's antipsychotic effects do not depend on blockade of 5-HT3 receptors.

Authors:  R F Squires; E Saederup
Journal:  Neurochem Res       Date:  1999-05       Impact factor: 3.996

10.  Aripiprazole differentially regulates the expression of Gad67 and γ-aminobutyric acid transporters in rat brain.

Authors:  Nina Peselmann; Andrea Schmitt; Peter J Gebicke-Haerter; Mathias Zink
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2012-09-12       Impact factor: 5.270
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