Psychoneuroendocrinology of children and adolescents.

This article reviews psychoneuroendocrinologic approaches to the understanding of internalizing disorders (depression and anxiety disorders) and externalizing disorders. This article discusses three specific psychoneuroendocrine systems: measures of the hypothalamic-pituitary-adrenal (HPA) axis, measure of the serotonergic function, and measures of the growth-hormone (GH) response to pharmacologic challenge. The hypothalamic-pituitary-adrenal (HPA) axis is the main system; understanding this system may reveal information on the permissive and etiologic relationship of stress to psychiatric disorder.