Literature DB >> 9667909

Inhibiting the assembly of protein-protein interfaces.

R Zutshi1, M Brickner, J Chmielewski.   

Abstract

Protein-protein association is found throughout mechanisms of cellular growth and differentiation, and viral replication. Inhibiting the assembly of protein complexes, therefore, presents itself as a novel means of inhibition for a wide variety of cellular and viral events. Peptides and small molecules that modify the overall quaternary structure of a selection of receptor-ligand interactions and oligomeric viral enzymes have been developed recently.

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Year:  1998        PMID： 9667909     DOI： 10.1016/s1367-5931(98)80036-7

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  20 in total

1.  Essential protein-protein interactions between Plasmodium falciparum thymidylate synthase and dihydrofolate reductase domains.

Authors:  S Shallom; K Zhang; L Jiang; P K Rathod
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2.  Genetic selection for dissociative inhibitors of designated protein-protein interactions.

Authors:  S H Park; R T Raines
Journal:  Nat Biotechnol       Date:  2000-08       Impact factor: 54.908

3.  Inhibition of chymotrypsin through surface binding using nanoparticle-based receptors.

Authors:  Nicholas O Fischer; Catherine M McIntosh; Joseph M Simard; Vincent M Rotello
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-02       Impact factor: 11.205

4.  Short constrained peptides that inhibit HIV-1 entry.

Authors:  Samuel K Sia; Peter A Carr; Andrea G Cochran; Vladimir N Malashkevich; Peter S Kim
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-04       Impact factor: 11.205

5.  Selective disruption of protein aggregation by cyclodextrin dimers.

Authors:  D K Leung; Z Yang; R Breslow
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

6.  Synthesis of the phenylpyridal scaffold as a helical peptide mimetic.

Authors:  Gregory T Bourne; Daniel J Kuster; Garland R Marshall
Journal:  Chemistry       Date:  2010-07-26       Impact factor: 5.236

7.  Therapeutic Targeting of Myc.

Authors:  Edward V Prochownik; Peter K Vogt
Journal:  Genes Cancer       Date:  2010-06

Review 8.  Targeting erbB receptors.

Authors:  Zheng Cai; Hongtao Zhang; Jing Liu; Alan Berezov; Ramachandran Murali; Qiang Wang; Mark I Greene
Journal:  Semin Cell Dev Biol       Date:  2010-09-17       Impact factor: 7.727

9.  Crystal structure of triosephosphate isomerase from Trypanosoma cruzi in hexane.

Authors:  X G Gao; E Maldonado; R Pérez-Montfort; G Garza-Ramos; M T de Gómez-Puyou; A Gómez-Puyou; A Rodríguez-Romero
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-31       Impact factor: 11.205

10.  Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions.

Authors:  Lyn-Marie Birkholtz; Carsten Wrenger; Fourie Joubert; Gordon A Wells; Rolf D Walter; Abraham I Louw
Journal:  Biochem J       Date:  2004-01-15       Impact factor: 3.857
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