UNLABELLED: The aim of this study was to assess the physical performance in long-term survivors of acute leukaemia in childhood and to evaluate the effects of anthracycline therapy. Electrocardiography, echocardiography and spiroergometry were carried out on 56 patients aged 9-28 years, of whom 44 patients had been treated with 15-483 mg/m2 doxorubicin (or equivalent). Acute leukaemia had been diagnosed 1.5-16 years earlier. Of the patients 75% reached normal maximal oxygen uptake, 69% normal oxygen uptake at the anaerobic threshold and 95% normal maximal work rate. Of the patients 75% achieved adequate values for maximal heart rate and 78% normal blood lactate concentration. No difference was seen between patients treated with and without anthracyclines. CONCLUSION: The results of this study provide little evidence for cardiopulmonary impairment in long-term survivors of ALL. Both the cardiac function, as evaluated by ECG and echocardiography, and the physical performance in spiroergometry are normal in a large number of these patients. Anthracycline treatment does not appear to have a negative effect on these parameters.
UNLABELLED: The aim of this study was to assess the physical performance in long-term survivors of acute leukaemia in childhood and to evaluate the effects of anthracycline therapy. Electrocardiography, echocardiography and spiroergometry were carried out on 56 patients aged 9-28 years, of whom 44 patients had been treated with 15-483 mg/m2 doxorubicin (or equivalent). Acute leukaemia had been diagnosed 1.5-16 years earlier. Of the patients 75% reached normal maximal oxygen uptake, 69% normal oxygen uptake at the anaerobic threshold and 95% normal maximal work rate. Of the patients 75% achieved adequate values for maximal heart rate and 78% normal blood lactate concentration. No difference was seen between patients treated with and without anthracyclines. CONCLUSION: The results of this study provide little evidence for cardiopulmonary impairment in long-term survivors of ALL. Both the cardiac function, as evaluated by ECG and echocardiography, and the physical performance in spiroergometry are normal in a large number of these patients. Anthracycline treatment does not appear to have a negative effect on these parameters.
Authors: Vesile Yildiz Kabak; Patrick Calders; Tulin Duger; Jibril Mohammed; Eric van Breda Journal: Support Care Cancer Date: 2018-09-25 Impact factor: 3.603
Authors: Gabriel Somarriba; Gabriela Lopez-Mitnik; David A Ludwig; Daniela Neri; Natasha Schaefer; Steven E Lipshultz; Gwendolyn B Scott; Tracie L Miller Journal: AIDS Res Hum Retroviruses Date: 2012-07-31 Impact factor: 2.205
Authors: E De Caro; F Fioredda; M G Calevo; A Smeraldi; M Saitta; G Hanau; M Faraci; F Grisolia; G Dini; G Pongiglione; R Haupt Journal: Arch Dis Child Date: 2005-09-27 Impact factor: 3.791
Authors: Emily S Tonorezos; Peter G Snell; Chaya S Moskowitz; Debra A Eshelman-Kent; Jennifer E Liu; Joanne F Chou; Stephanie M Smith; Andrea L Dunn; Timothy S Church; Kevin C Oeffinger Journal: Pediatr Blood Cancer Date: 2013-02-15 Impact factor: 3.167
Authors: Megan C Hoffman; Daniel A Mulrooney; Julia Steinberger; Jill Lee; K Scott Baker; Kirsten K Ness Journal: J Clin Oncol Date: 2013-06-24 Impact factor: 44.544
Authors: Regine Söntgerath; Julia Däggelmann; Sabine V Kesting; Corina S Rueegg; Torge-Christian Wittke; Simon Reich; Katharina G Eckert; Sandra Stoessel; Carolina Chamorro-Viña; Joachim Wiskemann; Peter Wright; Anna Senn-Malashonak; Vanessa Oschwald; Anne-Marie Till; Miriam Götte Journal: Pediatr Res Date: 2021-04-15 Impact factor: 3.953