Literature DB >> 9665972

Inhibition of Mycobacterium bovis BCG-induced tumor necrosis factor alpha secretion in human cells by transforming growth factor beta.

P Méndez-Samperio1, M Hernandez-Garay, A Nuñez Vazquez.   

Abstract

The effect of exogenous transforming growth factor beta (TGF-beta) on Mycobacterium bovis BCG-induced tumor necrosis factor alpha (TNF-alpha) production by human mononuclear cells was studied. It was found that TNF-alpha production by human cells stimulated with BCG was significantly inhibited by TGF-beta. The specificity of the observed inhibition was demonstrated, since the addition of an anti-TGF-beta neutralizing monoclonal antibody completely reversed the inhibitory effect. Furthermore, the suppressive effect of TGF-beta on TNF-alpha secretion in this system was not due to a direct cytotoxic effect, since cell viability was comparable in the presence or absence of TGF-beta. Interestingly, our results demonstrated comparative suppressive effects of TGF-beta and interleukin-10 on BCG-induced TNF-alpha secretion. Together, the data demonstrate, for the first time, that TGF-beta inhibits BCG-induced TNF-alpha secretion by human cells.

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Year:  1998        PMID： 9665972      PMCID： PMC95623          DOI： 10.1128/CDLI.5.4.588-591.1998

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  23 in total

1.  The global tuberculosis situation and the new control strategy of the World Health Organization.

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2.  Depletion of endogenous interleukin-10 augments interleukin-1 beta secretion by Mycobacterium bovis BCG-reactive human cells.

Authors:  P Méndez-Samperio; E Garcia-Martinez; M Hernandez-Garay; M Solis-Cardona
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4.  Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor.

Authors:  I E Flesch; S H Kaufmann
Journal:  Infect Immun       Date:  1990-08       Impact factor: 3.441

5.  Deactivation of macrophages by transforming growth factor-beta.

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Journal:  Nature       Date:  1988-07-21       Impact factor: 49.962

6.  Expression of tumor necrosis factor in vitro by human mononuclear phagocytes stimulated with whole Mycobacterium bovis BCG and mycobacterial antigens.

Authors:  S E Valone; E A Rich; R S Wallis; J J Ellner
Journal:  Infect Immun       Date:  1988-12       Impact factor: 3.441

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9.  The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection.

Authors:  V Kindler; A P Sappino; G E Grau; P F Piguet; P Vassalli
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  3 in total

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