| Literature DB >> 9665506 |
D A Gadkari1, T C Quinn, R R Gangakhedkar, S M Mehendale, A D Divekar, A R Risbud, K Chan-Tack, M Shepherd, C Gaydos, R C Bollinger.
Abstract
HIV infection status was determined in 302 consecutive patients with genital ulcer disease (GUD) presenting to two sexually transmitted disease (STD) clinics in Pune, India. Of the 71 (24%) individuals with HIV infection, 67 (94%) were HIV antibody-positive, and 4 (6%) were HIV antibody-negative but p24 antigen-positive at the time of presentation. HIV-1 DNA was detected in 24 (34%) specimens. The genital ulcers of all four acutely infected p24-antigenemic subjects were HIV-1 DNA-positive by polymerase chain reaction (PCR) assay, compared with 20 of 67 (30%) seropositive patients (p = .01). Presence of chancroid, GUD symptoms for > 10 days, and concurrent diagnosis of cervicitis or urethritis were significantly associated risk factors for HIV-1 DNA shedding in ulcers. Early GUD diagnosis and aggressive treatment of HIV-infected patients may significantly reduce secondary transmission of HIV to other sex partners.Entities:
Keywords: Acquired Immunodeficiency Syndrome; Asia; Biology; Chancroid; Clinical Research; Developing Countries; Diseases; Genital Effects, Female; Genital Effects, Male; Genitalia; Genitalia, Female; Genitalia, Male; Hiv Infections--transmission; India; Infections; Physiology; Reproductive Tract Infections; Research Methodology; Research Report; Risk Factors; Sexually Transmitted Diseases; Southern Asia; Urogenital System; Viral Diseases
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Year: 1998 PMID： 9665506 DOI： 10.1097/00042560-199807010-00012
Source DB: PubMed Journal: J Acquir Immune Defic Syndr Hum Retrovirol ISSN： 1077-9450