| Literature DB >> 9665167 |
R B Turner1, D L Smith, M E Zawrotny, M F Summers, M C Posewitz, D R Winge.
Abstract
The three dimensional structure of the N-terminal domain (residues 1-42) of the copper-responsive transcription factor Amtl from Candida glabrata has been determined by two-dimensional 1H-correlated nuclear magnetic resonance (NMR) methods. The domain contains an array of zinc-binding residues (Cys-X2-Cys-X8-Cys-X-His) that is conserved among a family of Cu-responsive transcription factors. The structure is unlike those of previously characterized zinc finger motifs, and consists of a three-stranded antiparallel beta-sheet with two short helical segments that project from one end of the beta-sheet. Conserved residues at positions 16, 18 and 19 form a basic patch that may be important for DNA binding.Entities:
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Year: 1998 PMID： 9665167 DOI： 10.1038/805
Source DB: PubMed Journal: Nat Struct Biol ISSN： 1072-8368