Literature DB >> 9664118

Quantitative analysis of CDKN2, p53 and retinoblastoma mRNA in human gastric carcinoma.

Y J Chen1, L S Shih, Y M Chen.   

Abstract

The mRNA level of CDKN2 (p16), retinoblastoma (Rb) and p53 in cancerous and non-cancerous tissue samples were compared using a semi-quantitative reverse-transcription-polymerase chain reaction method. The mean CDKN2 mRNA level of 10 gastric cancer specimens was significantly higher than that of their non-cancerous tissue samples (p=0.039). In contrast, the mRNA levels of Rb and p53 in gastric cancer tissues were both significantly lower than those in their non-cancerous tissue samples. Furthermore, both mRNA ratios of Rb/CDKN2 and p53/CDKN2 were significantly decreased in gastric cancer tissues. Therefore, suppression of both Rb and p53 and overexpression of CDKN2 may be associated with the tumorigenesis of gastric cancer.

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Year:  1998        PMID： 9664118

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  4 in total

1.  hTERT and TP53 deregulation in intestinal-type gastric carcinogenesis in non-human primates.

Authors:  Mariana Ferreira Leal; Danielle Queiroz Calcagno; André Salim Khayat; Tanielly Cristina Raiol Silva; José Augusto Pereira Carneiro Muniz; Paulo Pimentel Assumpção; Marília de Arruda Cardoso Smith; Rommel Rodríguez Burbano
Journal:  Clin Exp Med       Date:  2012-06-17       Impact factor: 3.984

2.  Expressing patterns of p16 and CDK4 correlated to prognosis in colorectal carcinoma.

Authors:  Po Zhao; Ying-Chuan Hu; Ian C Talbot
Journal:  World J Gastroenterol       Date:  2003-10       Impact factor: 5.742

3.  Helicobacter pylori infection generated gastric cancer through p53-Rb tumor-suppressor system mutation and telomerase reactivation.

Authors:  Jing Lan; Yong-Yan Xiong; Yi-Xian Lin; Bi-Cheng Wang; Ling-Ling Gong; Hui-Sen Xu; Guang-Song Guo
Journal:  World J Gastroenterol       Date:  2003-01       Impact factor: 5.742

Review 4.  Genetic and molecular aspects of Helicobacter pylori in gastritis, pre- cancerous conditions and gastric adenocrcinoma.

Authors:  Mohammad Shadifar; Ramin Ataee; Amin Ataie; Ali Morad Heydari Gorgi; Nafiseh Nasri Nasrabadi; Somayyeh Nouri
Journal:  Gastroenterol Hepatol Bed Bench       Date:  2015
  4 in total

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