OBJECTIVE: The purpose of this report is to examine the differences at baseline in demographic, medical, and ophthalmic characteristics between blacks and whites enrolled in the Advanced Glaucoma Intervention Study (AGIS), a multicenter, randomized, clinical trial. DESIGN: Multicenter, randomized, controlled trial. PARTICIPANTS: A total of 332 black patients (451 eyes), 249 white patients (325 eyes), and 10 patients of other races (13 eyes) with open-angle glaucoma that could not be controlled by medical therapy alone participated. INTERVENTION: There was no intervention performed. METHODS: The investigators compare the baseline demographic, medical, and ophthalmic characteristics of black and white patients, adjusting the comparisons for age and gender. RESULTS:Blacks in the study were younger than whites and had more systemic hypertension and diabetes than whites. The visual field defects of blacks on average were substantially more severe than those of whites. Intraocular pressures and visual acuity scores were similar in the two groups. Blacks were more hyperopic and had relatively fewer disk rim hemorrhages than whites. CONCLUSIONS: The findings of the current study concur with those of previous clinical studies of open-angle glaucoma that visual field defects are more severe in blacks than whites.
RCT Entities:
OBJECTIVE: The purpose of this report is to examine the differences at baseline in demographic, medical, and ophthalmic characteristics between blacks and whites enrolled in the Advanced Glaucoma Intervention Study (AGIS), a multicenter, randomized, clinical trial. DESIGN: Multicenter, randomized, controlled trial. PARTICIPANTS: A total of 332 black patients (451 eyes), 249 white patients (325 eyes), and 10 patients of other races (13 eyes) with open-angle glaucoma that could not be controlled by medical therapy alone participated. INTERVENTION: There was no intervention performed. METHODS: The investigators compare the baseline demographic, medical, and ophthalmic characteristics of black and white patients, adjusting the comparisons for age and gender. RESULTS: Blacks in the study were younger than whites and had more systemic hypertension and diabetes than whites. The visual field defects of blacks on average were substantially more severe than those of whites. Intraocular pressures and visual acuity scores were similar in the two groups. Blacks were more hyperopic and had relatively fewer disk rim hemorrhages than whites. CONCLUSIONS: The findings of the current study concur with those of previous clinical studies of open-angle glaucoma that visual field defects are more severe in blacks than whites.
Authors: David S Friedman; Roger C W Wolfs; Benita J O'Colmain; Barbara E Klein; Hugh R Taylor; Shelia West; M Cristina Leske; Paul Mitchell; Nathan Congdon; John Kempen Journal: Arch Ophthalmol Date: 2004-04
Authors: Sharon Bakalash; Gil Ben-Shlomo; Gil Ben Shlomo; Eyal Aloni; Iftach Shaked; Larry Wheeler; Ron Ofri; Michal Schwartz Journal: J Mol Med (Berl) Date: 2005-08-12 Impact factor: 4.599
Authors: Andrew H Nguyen; Nima Fatehi; Pablo Romero; Arezoo Miraftabi; EunAh Kim; Esteban Morales; JoAnn Giaconi; Anne L Coleman; Simon K Law; Joseph Caprioli; Kouros Nouri-Mahdavi Journal: JAMA Ophthalmol Date: 2018-10-01 Impact factor: 7.389
Authors: Christiane R Rolim-de-Moura; Augusto Paranhos; Mohamed Loutfi; David Burton; Richard Wormald; Jennifer R Evans Journal: Cochrane Database Syst Rev Date: 2022-08-09
Authors: Joan M O'Brien; Rebecca J Salowe; Raymond Fertig; Julia Salinas; Maxwell Pistilli; Prithvi S Sankar; Eydie Miller-Ellis; Amanda Lehman; Windell H A Murphy; Melissa Homsher; Katelyn Gordon; Gui-Shuang Ying Journal: Am J Ophthalmol Date: 2018-03-17 Impact factor: 5.258
Authors: Ronald L Fellman; Cynthia Mattox; Kuldev Singh; Brian Flowers; Brian A Francis; Alan L Robin; Michelle R Butler; Manjool M Shah; JoAnn A Giaconi; Arsham Sheybani; Brian J Song; Joshua D Stein Journal: Ophthalmol Glaucoma Date: 2020 Jan - Feb
Authors: Alon Skaat; Carlos Gustavo De Moraes; Christopher Bowd; Pamela A Sample; Christopher A Girkin; Felipe A Medeiros; Robert Ritch; Robert N Weinreb; Linda M Zangwill; Jeffrey M Liebmann Journal: Ophthalmology Date: 2016-04-23 Impact factor: 12.079