Specific changes in food intake elicited by blockade or activation of glutamate receptors in the nucleus accumbens shell.

Blockade of non-N-methyl-D-aspartic acid (NMDA) ionotropic glutamate receptors in the nucleus accumbens shell (AcbSh) with 6,7-dinitroquinoxaline-2,3-dione (DNQX) elicits intense feeding in satiated rats. In order to determine whether or not this feeding is part of a general behavioral activation, we observed the effect of intra-AcbSh DNQX injections on intake of solid food, liquid food, and water, and on gnawing behavior. In addition, we investigated the possibility that activation of a subset of these receptors with (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) could suppress feeding. DNQX significantly increased intake of solid and liquid food, but did not significantly affect water intake or gnawing behavior. Furthermore, injections of AMPA into the AcbSh suppressed deprivation-induced feeding and intake of a palatable 5% sucrose solution without affecting water intake in water-deprived rats. Taken together, these data suggest that DNQX is acting on a system specifically involved with the regulation of food intake.