L M Resar1, M A Helfaer. 1. Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, Md. 21205, USA.
Abstract
OBJECTIVE: We report recurrent seizures in a neonate after intravenous lidocaine administration at the recommended dose for intubation and supplementation of general anesthesia. STUDY DESIGN: Further evaluation of this case included determination of serum lidocaine level, serum electrolyte levels, and arterial blood gas values; cerebral spinal fluid analysis; an electroencephalogram; head ultrasonography; brain stem auditory evoked response testing; and a complete developmental evaluation. Previously published literature discussing lidocaine toxicity and pharmacokinetics is reviewed. RESULTS: The lidocaine level in the patient was 0.3 mg/L 2 hours after the last dose was administered. Results of the remaining studies were within normal limits, and the patient had no additional seizures several months after birth. CONCLUSION: We caution that lidocaine administration to newborn infants at previously accepted doses may result in life-threatening side effects, including prolonged seizures.
OBJECTIVE: We report recurrent seizures in a neonate after intravenous lidocaine administration at the recommended dose for intubation and supplementation of general anesthesia. STUDY DESIGN: Further evaluation of this case included determination of serum lidocaine level, serum electrolyte levels, and arterial blood gas values; cerebral spinal fluid analysis; an electroencephalogram; head ultrasonography; brain stem auditory evoked response testing; and a complete developmental evaluation. Previously published literature discussing lidocainetoxicity and pharmacokinetics is reviewed. RESULTS: The lidocaine level in the patient was 0.3 mg/L 2 hours after the last dose was administered. Results of the remaining studies were within normal limits, and the patient had no additional seizures several months after birth. CONCLUSION: We caution that lidocaine administration to newborn infants at previously accepted doses may result in life-threatening side effects, including prolonged seizures.
Authors: Mirte M Malingré; Linda G M Van Rooij; Carin M A Rademaker; Mona C Toet; Tessa F F T Ververs; Charlotte van Kesteren; Linda S de Vries Journal: Eur J Pediatr Date: 2006-05-12 Impact factor: 3.183
Authors: Linda G M van Rooij; Mona C Toet; Karin M A Rademaker; Floris Groenendaal; Linda S de Vries Journal: Eur J Pediatr Date: 2004-08-07 Impact factor: 3.183