Preparation of a novel functional hydrogel consisting of sulfated glucoside-bearing polymer: activation of basic fibroblast growth factor.

Sulfated poly(glucosyloxyethyl methacrylate) [poly(GEMA)-sulfate] and its hydrogel were synthesized and evaluated to develop novel tissue regeneration assist devices. The poly(GEMA)-sulfate hydrogel was obtained by gamma-ray irradiation. Basic fibroblast growth factor (bFGF) was expected to be subsequently incorporated with hydrogel matrices and activated or released from the matrices. A sustained release of bFGF from the poly(GEMA)-sulfate hydrogel was not realized; however, bFGF from poly(GEMA)-sulfate hydrogel was effectively activated. Poly(GEMA)-sulfate hydrogels are thought to be potential component materials for a tissue engineering matrix.