Literature DB >> 9659598

Molecular calculations of poly(ethylene glycol) transport across a swollen poly(acrylic acid)/mucin interface.

N A Peppas1.   

Abstract

The transport of poly(ethylene glycol) chains than can promote mucoadhesion across the interface between lightly cross-linked poly(acrylic acid) and mucin may be analyzed as a function of molecular characteristics using theories of chain penetration in a dilute network. The fracture energy for the ensuing adhesive bond is proportional to the number of polymer chains crossing the interface, which, in turn, is related to the polymer volume fraction, the chain diffusion coefficient, and the degree of polymerization. Relevant calculations were performed for a number of cross-linked poly(acrylic acid) gels and three different types of poly(ethylene glycol) chains.

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Year:  1998        PMID： 9659598     DOI： 10.1163/156856298x00028

Source DB:  PubMed          Journal:  J Biomater Sci Polym Ed        ISSN： 0920-5063            Impact factor:   3.517


  8 in total

1.  Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo.

Authors:  Katharina Maisel; Mihika Reddy; Qingguo Xu; Sumon Chattopadhyay; Richard Cone; Laura M Ensign; Justin Hanes
Journal:  Nanomedicine (Lond)       Date:  2016-05-12       Impact factor: 5.307

2.  Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse.

Authors:  Katharina Maisel; Laura Ensign; Mihika Reddy; Richard Cone; Justin Hanes
Journal:  J Control Release       Date:  2014-11-04       Impact factor: 9.776

3.  Key functions in polymer carriers for intestinal absorption of insulin.

Authors:  Koji Nakamura; Mariko Morishita; Junpei Ehara; Yoshinori Onuki; Tetsuo Yamagata; Noriyasu Kamei; Anthony M Lowman; Nicholaos A Peppas; Kozo Takayma
Journal:  Int J Pharm       Date:  2007-11-09       Impact factor: 5.875

4.  Molecular aspects of mucoadhesive carrier development for drug delivery and improved absorption.

Authors:  Nicholas A Peppas; J Brock Thomas; James McGinty
Journal:  J Biomater Sci Polym Ed       Date:  2009       Impact factor: 3.517

Review 5.  Engineering design and molecular dynamics of mucoadhesive drug delivery systems as targeting agents.

Authors:  Laura Serra; Josep Doménech; Nicholas A Peppas
Journal:  Eur J Pharm Biopharm       Date:  2008-10-17       Impact factor: 5.571

6.  Mechanistic insight into the interaction of gastrointestinal mucus with oral diblock copolymers synthesized via ATRP method.

Authors:  Jiao Liu; Jie Cao; Jianhua Cao; Shangcong Han; Yan Liang; Mingfeng Bai; Yong Sun
Journal:  Int J Nanomedicine       Date:  2018-05-15

7.  Stimuli-Responsive Biomaterials for Vaccines and Immunotherapeutic Applications.

Authors:  Noah Pacifici; Amir Bolandparvaz; Jamal S Lewis
Journal:  Adv Ther (Weinh)       Date:  2020-08-02

Review 8.  Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems.

Authors:  Deepak A Subramanian; Robert Langer; Giovanni Traverso
Journal:  J Nanobiotechnology       Date:  2022-08-06       Impact factor: 9.429
  8 in total

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