Literature DB >> 9659249

A method for the confirmation and identification of drugs of misuse in urine using solid phase extraction and gas-liquid chromatography with mass spectrometry.

J H Galloway1, M Ashford, I D Marsh, M Holden, A R Forrest.   

Abstract

A method is described for the confirmation/identification of a range of commonly misused drugs in urine samples. The method has been used for two years without problems for a range of purposes including hospital/clinic drugs of misuse screening and for toxicology in coroner's cases. Urine samples which have given a positive result on immunochemical screening for a particular drug group or groups (for example, opiates) can be processed with identification of the drugs present using a single procedure. Bond ElutCertify columns are used for the extraction of drugs from the samples followed by propionylation and gas chromatography with mass selective detection.

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Year:  1998        PMID： 9659249      PMCID： PMC500681          DOI： 10.1136/jcp.51.4.326

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  8 in total

1.  Solid-phase extraction and HPLC-UV confirmation of drugs of abuse in urine.

Authors:  S D Ferrara; L Tedeschi; G Frison; F Castagna
Journal:  J Anal Toxicol       Date:  1992 Jul-Aug       Impact factor: 3.367

2.  Rendering the "poppy-seed defense" defenseless: identification of 6-monoacetylmorphine in urine by gas chromatography/mass spectroscopy.

Authors:  S J Mulé; G A Casella
Journal:  Clin Chem       Date:  1988-07       Impact factor: 8.327

3.  The effect of temperature and pH on the deacetylation of diamorphine in aqueous solution and in human plasma.

Authors:  D A Barrett; A L Dyssegaard; P N Shaw
Journal:  J Pharm Pharmacol       Date:  1992-07       Impact factor: 3.765

4.  Disposition of heroin and its metabolites in heroin-related deaths.

Authors:  B A Goldberger; E J Cone; T M Grant; Y H Caplan; B S Levine; J E Smialek
Journal:  J Anal Toxicol       Date:  1994 Jan-Feb       Impact factor: 3.367

5.  Rapid, simultaneous quantification of morphine, codeine, and hydromorphone by GC/MS.

Authors:  J J Saady; N Narasimhachari; R V Blanke
Journal:  J Anal Toxicol       Date:  1982 Sep-Oct       Impact factor: 3.367

6.  Simultaneous analysis of codeine, morphine, and heroin after B-glucuronidase hydrolysis.

Authors:  M Zezulak; J J Snyder; S B Needleman
Journal:  J Forensic Sci       Date:  1993-11       Impact factor: 1.832

7.  Simultaneous determination of opiates, cocaine and major metabolites of cocaine in human hair by gas chromotography/mass spectrometry (GC/MS).

Authors:  P Kintz; P Mangin
Journal:  Forensic Sci Int       Date:  1995-05-22       Impact factor: 2.395

8.  Simultaneous determination of drugs of abuse (opiates, cocaine and amphetamine) in human hair by GC/MS and its application to a methadone treatment program.

Authors:  M R Moeller; P Fey; R Wennig
Journal:  Forensic Sci Int       Date:  1993-12       Impact factor: 2.395
  8 in total
  1 in total

1.  Detection of drug misuse--an addictive challenge.

Authors:  J H Galloway; I D Marsh
Journal:  J Clin Pathol       Date:  1999-10       Impact factor: 3.411
  1 in total

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